The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The phytochemical 3,3 ′-Diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells
Androgen receptor (AR) is a nuclear receptor transcription factor that plays a central role in normal prostate physiology as well as in prostate cancer biology (PCa). Phytochemicals like 3,3 ′-Diindolylmethane (DIM) have emerged as promising therapeutic agents against PCa. DIM has been shown to influence both AR activity and other epigenetic regulators in PCa cells. However, it is not known if DIM contributes to PCa suppression via epigenetic regulation of AR target genes. Here we ass essed epigenetic regulation of important AR-target genes in LNCaP PCa cells treated with DIM. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Zoraya Palomera-Sanchez, Gregory W. Watson, Carmen P. Wong, Laura M. Beaver, David E. Williams, Roderick H. Dashwood, Emily Ho Source Type: research

Dietary fatty acids modulate adipocyte TNFa production via regulation of its DNA promoter methylation levels
In this study we investigate whether the effect of dietary fatty acids on TNFa released from adipocytes might be associated with modifications of the TNFa promoter DNA methylation status. A group of rats was assigned to three diets with a different composition of saturated, monounsaturated and polyunsaturated fatty acids. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Eva Garc ía-Escobar, Roberto Monastero, Sara García-Serrano, Juan M. Gómez-Zumaquero, Ana Lago-Sampedro, Elehazara Rubio-Martín, Natalia Colomo, Francisca Rodríguez-Pacheco, Federico Soriguer, Gemma Rojo-Martínez Source Type: research

The change in retinoic acid receptor signaling induced by prenatal marginal vitamin A deficiency and its effects on learning and memory
This study investigated the prenatal marginal vitamin A deficiency (mVAD)-related impairment in learning and memory and the interactions between RAR α, Src, and NR1. Learning and memory were assessed in adult rats that were exposed to prenatal mVAD with Morris water maze. The average escape time was longer in mVAD rats, and they passed the hidden platform fewer times during the memory retention test than normal vitamin A intake (VAN) rats. The mRNA and protein levels of RARα, Src, and NR1 in mVAD rats were significantly lower than those in VAN rats. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Xuan Zhang, Xingang Yuan, Lijun Chen, Hua Wei, Jie Chen, Tingyu Li Source Type: research

Alpha-glucosidase Inhibitory Effect of Resveratrol and Piceatannol
Dietary polyphenols have been shown to inhibit α-glucosidase, an enzyme target of some anti-diabetic drugs. Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast α-glucosidase. This triggered our interest to synthesize analogs and determine their effect on mammalian α-glucosidase activity. Usin g either sucrose or maltose as substrate resveratrol, piceatannol and 3′-hydroxypterostilbene showed strong inhibition of mammalian α-glucosidase activity; pinostilbene, cis- and trans-desoxyrhapontigenin had moderate inhibition. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Albert J. Zhang, Agnes M. Rimando, Cassia S. Mizuno, Suresh T. Mathews Source Type: research

The Effects of Fatty Acid Composition on Cardiac Hypertrophy and Function in Mouse Models of Diet-Induced Obesity
High fat diets (HFDs) are used frequently to study the development of cardiac dysfunction in animal models of obesity and diabetes. However, impairment in systolic function, often reported as declining ejection fraction, may not consistently occur in a given time frame which could be contributable to a variety of factors within the experimental design. One major factor may be the amounts of saturated and unsaturated fatty acids (FAs) that are present in the diet. To determine whether the FA content and composition was a critical determinant in the development of cardiac dysfunction in response to high fat feeding, we fed a...
Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Son Nguyen, Dan Shao, Loreta C. Tomasi, Alyssa Braun, Ana Barbosa Marcondes de Mattos, Yong Seon Choi, Outi Villet, Nathan Roe, Carliana R. Halterman, Rong Tian, Stephen C. Kolwicz Source Type: research

Effects of a whey proteins supplementation on oxidative stress, body composition and glucose metabolism among overweight people affected by diabetes mellitus o impaired fasting glucose: A pilot study
Obesity and diabetes mellitus type 2 (DM2) are characterized by chronic inflammation and oxidative stress [Donath et al. 2013] and this leads to cardiovascular diseases [Hulsmans& Holvoet 2010]. Whey proteins (WP) have antioxidant [Chitapanarux et al. 2009], anti-inflammatory [Sugawara et al. 2012] and hypoglycemic activities [Mignone et al. 2015], while data on weight, body composition [Frestedt et al. 2008; Aldrich et al. 2011] and blood pressure are conflicting [Kawase et al. 2000; Lee et al. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 20, 2017 Category: Biochemistry Authors: Chiara Flaim, Michael Kob, Angela M. Di Pierro, Markus Herrmann, Lucio Lucchin Source Type: research

Oral feeding with polyunsaturated fatty acids fosters haematopoiesis and thrombopoiesis in healthy and bone marrow-transplanted mice
Haematopoietic stem cells play the vital role of maintaining appropriate levels of cells in blood. Therefore regulation of their fate is essential for their effective therapeutic use. Here we report the role of poly unsaturated fatty acids (PUFAs) in regulating haematopoiesis which has not been explored well so far. Mice were fed daily for ten days with n-6/-n-3 PUFAs, viz. Linoleic acid(LA), Arachidonic acid(AA), Alpha-linolenic acid(ALA) and Docosahexanoic acid (DHA) in four separate test groups with PBS fed mice as control set. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 17, 2017 Category: Biochemistry Authors: Kedar Limbkar, Ankita Dhenge, Dipesh D. Jadhav, Hirekodathakallu V. Thulasiram, Vaijayanti Kale, Lalita Limaye Source Type: research

Table of Contents (create from IPS)
(Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 12, 2017 Category: Biochemistry Source Type: research

Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy
Sirtuin (SIRT1) inactivation underlies the pathogenesis of insulin resistance and hyperglycaemia associated vascular complications, but its role in diabetic neuropathy (DN) has not been yet explored. We have evaluated hyperglycaemia induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1 directed AMP kinase (AMPK) and peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1 α) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, i.p. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 11, 2017 Category: Biochemistry Authors: Veera Ganesh Yerra, Anil Kumar Kalvala, Ashutosh Kumar Source Type: research

Dietary Salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat diet-induced obese rats
Previous studies suggest that dietary salecan (a water-soluble β-glucan) effectively reduce high-fat diet-induced adiposity through disturbing bile acid-promoted emulsification in mice. However, the effects of salecan on metabolic genes and metabolites involved lipid accumulation are mostly unknown. Here, we conformed that dietary 3% and 6% salecan for 4 weeks markedly decreased fat accumulation in liver and adipose tissue in high-fat diet rats, displaying a decrease in mRNA levels of SREBP1-C,FAS,SCD1,ACC1 involved in de novo lipogenesis and a reduction of levels of GPAT1,DGAT1,DGAT2 related to triglyceride (TG) synthesi...
Source: The Journal of Nutritional Biochemistry - May 5, 2017 Category: Biochemistry Authors: Qi Sun, Minghui Li, Xiao Yang, Xi Xu, Junsong Wang, Jianfa Zhang Source Type: research

Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps
Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine. L-arginine is necessary for cancer development and progression, including an important role in colorectal cancer pathogenesis. Furthermore, previous studies found both calcium and magnesium inhibit the transport of arginine. Thus, calcium, magnesium or calcium:magnesium intake ratio may interact with polymorphisms in the SLC7A2 gene in associations with colorectal cancer. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 5, 2017 Category: Biochemistry Authors: Pin Sun, Xiangzhu Zhu, Martha J Shrubsole, Reid M Ness, Elizabeth A Hibler, Qiuyin Cai, Jirong Long, Zhi Chen, Guoliang Li, Lifang Hou, Walter E Smalley, Todd L. Edwards, Edward Giovannucci, Wei Zheng, Qi Dai Source Type: research

Table of Contents
(Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 27, 2017 Category: Biochemistry Source Type: research

Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors
Dietary fish oils have potential for prevention of colon cancer, and yet the mechanisms of action in normal and tumor colon tissues are not well defined. Here we evaluated the impact of the colonic fatty acid milieu on formation of prostaglandins and other eicosanoids. Distal tumors in rats were chemically induced to model inflammatory colonic carcinogenesis. After 21 weeks of feeding with either a fish oil diet containing an eicosapentaenoic acid: ω-6 fatty acid ratio of 0.4 or a Western fat diet, the relationships between colon fatty acids and prostaglandin E2 (PGE2) concentrations were evaluated. (Source: The Journal o...
Source: The Journal of Nutritional Biochemistry - April 24, 2017 Category: Biochemistry Authors: Zora Djuric, Muhammad Nadeem Aslam, Becky R. Simon, Ananda Sen, Yan Jiang, Jianwei Ren, Rena Chan, Tanu Soni, T.M. Rajendiran, William L. Smith, Dean E. Brenner Source Type: research

Synergistic effect of low K and D vitamin status on arterial stiffness in a general population
Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix γ-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA, and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 22, 2017 Category: Biochemistry Authors: Otto Mayer, Jitka Seidlerov á, Peter Wohlfahrt, Jan Filipovský, Renata Cífková, Václava Černá, Alena Kučerová, Martin Pešta, Radka Fuchsová, Ondřej Topolčan, Kelly M.C. Jardon, Nadja E.A. Drummen, Cees Vermeer Source Type: research

Xanthohumol, a Hop-derived Prenylated Flavonoid, Promotes Macrophage Reverse Cholesterol Transport
Xanthohumol, a prominent prenyl flavonoid from the hop plant (Humulus lupulus L.), is suggested to be anti-atherogenic since it reportedly increases HDL-cholesterol levels. It is not clear whether xanthohumol promotes reverse cholesterol transport (RCT), the most important anti-atherogenic property of HDL therefore we investigated the effects of xanthohumol on macrophage-to-feces RCT using a hamster model as a CETP-expressing species. In vivo RCT experiments showed xanthohumol significantly increased fecal appearance of the tracer derived from intraperitoneally injected [3H]-cholesterol-labeled macrophages. (Source: The Jo...
Source: The Journal of Nutritional Biochemistry - April 22, 2017 Category: Biochemistry Authors: Hiroshi Hirata, Harumi Uto-Kondo, Masatsune Ogura, Makoto Ayaori, Kazusa Shiotani, Ami Ota, Youichi Tsuchiya, Katsunori Ikewaki Source Type: research