Oral feeding with polyunsaturated fatty acids fosters haematopoiesis and thrombopoiesis in healthy and bone marrow-transplanted mice

Haematopoietic stem cells play the vital role of maintaining appropriate levels of cells in blood. Therefore regulation of their fate is essential for their effective therapeutic use. Here we report the role of poly unsaturated fatty acids (PUFAs) in regulating haematopoiesis which has not been explored well so far. Mice were fed daily for ten days with n-6/-n-3 PUFAs, viz. Linoleic acid(LA), Arachidonic acid(AA), Alpha-linolenic acid(ALA) and Docosahexanoic acid (DHA) in four separate test groups with PBS fed mice as control set.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research