The Journal of Nutritional Biochemistry The Journal of Nutritional Biochemistry RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preventive effects of dietary walnuts on high fat-induced hepatic fat accumulation, oxidative stress and apoptosis in mice
Dietary walnuts show significant antioxidant properties. We hypothesized that dietary walnut supplementation would prevent high fat diet (HFD)-induced hepatic apoptosis, at least partially, by decreasing HFD-increased levels of oxidative/nitrative stress and hepatic steatosis. Male C57BL/6J mice were fed a regular rodent chow or HFD (45% energy-derived) with or without walnuts (21.5% energy-derived) for 6weeks. Liver histological analysis revealed significantly elevated fat accumulation in HFD-fed mice compared to the mice fed chow or HFD+walnuts (HFD+W). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 21, 2016 Category: Biochemistry Authors: Youngshim Choi, Mohamed A. Abdelmegeed, Byoung-Joon Song Source Type: research

Mulberry fruit ameliorates Parkinson's disease-related pathology by reducing α-synuclein and ubiquitin levels in an 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model
Mulberry fruit, which has been long used in traditional oriental medicine, was reported to ameliorate motor dysfunction and dopaminergic neuronal degeneration via antioxidant and anti-apoptotic effects in an animal model of Parkinson's disease (PD).>95% of PD patients exhibit non-motor problems such as olfactory dysfunction and gastrointestinal constipation, which are generally considered to be early symptoms of PD. However, few studies have actually examined potential drugs to treat early PD symptoms. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 21, 2016 Category: Biochemistry Authors: Pil Sung Gu, Minho Moon, Jin Gyu Choi, Myung Sook Oh Source Type: research

Effects of chlorogenic acid, caffeine and coffee on components of the purinergic system of STZ-induced diabetic rats
We evaluated the effect of chlorogenic acid (CGA), caffeine (CA) and coffee (CF) on components of the purinergic system from the cerebral cortex and platelets of streptozotocin (STZ)-induced diabetic rats. Animals were divided into eight groups, control animals treated with: I – water (WT); II – CGA (5 mg/kg); III – CA (15 mg/kg); IV– CF (0.5 g/kg); and diabetic animals treated with: V – WT; VI – CGA (5 mg/kg); VII – CA (15 mg/kg); VIII – CF (0.5 g/kg). Our results showed an increase (173%) in AMP hydrolysis in the cerebral cortex of diabetic rats. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 21, 2016 Category: Biochemistry Authors: Naiara Stefanello, Roberta Schmatz, Luciane Belmonte Pereira, Andr éia Machado Cardoso, Sabina Passamonti, Rosélia Maria Spanevello, Gustavo Thomé, Giovanna Medeiros Tavares de Oliveira, Luiza Wilges Kist, Maurício Reis Bogo, Vera Maria Morsch, Maria Source Type: research

Concomitant ingestion of lactic acid bacteria and black tea synergistically enhances flavonoid bioavailability and attenuates D-galactose-induced oxidative stress in mice via modulating glutathione antioxidant system
Black tea (BT) has been positively linked to improved redox status while its efficacy is limited due to the low bioavailability of BT flavonoids. In addition to the direct antioxidant activity, flavonoids regulate redox balance via inducing endogenous antioxidants, particularly glutathione (GSH) and GSH-dependent antioxidant enzymes. This work first examined the effect of lactic acid bacteria (LAB) and BT alone or in combination on flavonoid bioavailability and metabolism; next, the effect of LAB-fermented BT diet in attenuating oxidative stress in mice and the underlying mechanisms were studied. (Source: The Journal of Nu...
Source: The Journal of Nutritional Biochemistry - September 17, 2016 Category: Biochemistry Authors: Danyue Zhao, Nagendra P. Shah Source Type: research

Drinks containing anthocyanin-rich blackcurrant extract decrease postprandial blood glucose, insulin and incretin concentrations
Blackcurrants are rich in polyphenolic glycosides called anthocyanins, which may inhibit postprandial glycemia. The aim was to determine the dose-dependent effects of blackcurrant extract on postprandial glycemia. Men and postmenopausal women (14 M, 9 W, mean age 46 y, SD 14) were enrolled into a randomized, double-blind, crossover trial. Low sugar fruit drinks containing blackcurrant extract providing150 mg (L-BE), 300 mg (M-BE) and 600 mg (H-BE) total anthocyanins or no blackcurrant extract (CON) were administered immediately before a high-carbohydrate meal. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 13, 2016 Category: Biochemistry Authors: Monica L. Castro Acosta, Leanne Smith, Rosalind J. Miller, Danielle I. McCarthy, Jonathan A. Farrimond, Wendy L. Hall Source Type: research

Sesame oil improves functional recovery by attenuating nerve oxidative stress in a mouse model of acute peripheral nerve injury: role of Nrf-2
Peripheral nervous injury (PNI) is a common form of trauma in modern society, especially in sport players. Despite the advance of therapy for PNI, the recovery of function can never reach the pre-injury level after treatments. Recently, inhibiting neural oxidative stress shows a beneficial effect in improving functional recovery after PNI. In addition, sesame oil has been reported to possess the excellent anti-oxidative properties. However, whether sesame oil can improve the functional recovery after PNI by its anti-oxidative effect has never been investigated. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 13, 2016 Category: Biochemistry Authors: Che-Chia Hsu, Hui-Cheng Huang, Po-Ting Wu, Ta-Wei Tai, I-Ming Jou Source Type: research

Akt drives buffalo casein derived novel peptide mediated osteoblast differentiation
Milk is a potential nutraceutical with wide range of bioactive compounds that are antioxidative, antimicrobial, antithrombotic, immunomodulatory, opioid and antihypertensive. Various intervention studies with milk reflect its stupendous role in elevating bone mineral density. Milk and milk products have shown a preventive effect in bone loss during pre- and post-menopausal women. Since, milk is proved to have a vital role in bone health promotion; there is a need to identify bioactive compounds within it. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 13, 2016 Category: Biochemistry Authors: Srinu Reddi, Naveen Kumar, Rishika Vij, Sansui Bello Mada, Suman Kapila, Rajeev Kapila Source Type: research

Sub-chronic administration of ascorbic acid elicits antidepressant-like effect and modulates cell survival signaling pathways in mice
In this study, we examined the ability of sub-chronic ascorbic acid administration to produce an antidepressant-like effect in the mouse tail suspension test (TST). Moreover, we investigated the effect of this vitamin on hippocampal and cerebrocortical brain-derived neurotrophic factor (BDNF) immunocontent, phosphorylation of protein kinase B (AKT), extracellular signal-regulated kinase (ERK), p38MAPK and c-Jun. N-terminal kinase (JNK). Fluoxetine (10 mg/kg, positive control, p.o.) or ascorbic acid (0.1 and 1 mg/kg), administered once daily for 21 days, produced a significant antidepressant-like effect in the TST. (Source:...
Source: The Journal of Nutritional Biochemistry - September 13, 2016 Category: Biochemistry Authors: Morgana Moretti, Josiane Budni, Camille Mertins Ribeiro, D ébora Kurrle Rieger, Rodrigo Bainy Leal, Ana Lúcia S. Rodrigues Source Type: research

An ω-3 enriched diet alone does not attenuate CCl4-induced hepatic fibrosis
In this study we fed CCl4-treated mice a high ω-3 diet (using a mix of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) ethyl esters). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 13, 2016 Category: Biochemistry Authors: Todd R. Harris, Sean Kodani, Jun Yang, Denise M. Imai, Bruce D. Hammock Source Type: research

Fatty-acid-mediated hypothalamic inflammation and epigenetic programming
A high-fat diet is the main environmental cue that has been studied in the hypothalamus since the discovery of its connection with hypothalamic inflammation. Current evidence shows hypothalamic inflammation as a likely mechanism for the dysregulation on the homeostatic control of energy balance, which leads to metabolic alterations and obesity. Although this mechanism seems to be reversible when set during adulthood, we argue whether dietary fatty acids, during critical periods of development, could affect hypothalamic function permanently and set an increased susceptibility to obesity. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 8, 2016 Category: Biochemistry Authors: Helena C. Cesar, Luciana Pellegrini Pisani Source Type: research

Fatty acid-mediated hypothalamic inflammation and epigenetic programming
A high fat diet is the main environmental cue that has been studied in the hypothalamus since the discovery of its connection with hypothalamic inflammation. Current evidence shows hypothalamic inflammation as a likely mechanism for the dysregulation on the homeostatic control of energy balance, which leads to metabolic alterations and obesity. Although this mechanism seems to be reversible when set during adulthood, we argue whether dietary fatty acids, during critical periods of development, could affect hypothalamic function permanently and set an increased susceptibility to obesity. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 8, 2016 Category: Biochemistry Authors: Helena C. Cesar, L.P. Pisani Source Type: research

Soy isoflavones (Glycine max) ameliorates hypertriglyceridemia and hepatic steatosis in high fat fed ovariectomised Wistar rats (An experimental model of postmenopausal obesity)
Obesity emerged as the major risk factor for metabolic syndrome. Postmenopausal women are more prone to develop obesity than premenopausal women. The absence of safe and effective conventional treatments for postmenopausal obesity has changed the focus to natural products as alternative remedy. We investigated the molecular basis of the effect of soy isoflavones on hypertriglyceridemia and hepatic steatosis in an animal model of postmenopausal obesity. Ovariectomised (OVX) and sham operated Wistar rats were fed with high fat diet (HFD) and normal diet (ND) for eight weeks with and without soy isoflavones extract (SIF, 150m...
Source: The Journal of Nutritional Biochemistry - September 7, 2016 Category: Biochemistry Authors: P. Sankar, P. Rajaa Muthu, Zachariah Bobby, Sajini Elizabeth Jacob, M.G. Sridhar Source Type: research

Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia
Folic acid (FA) deficiency is not only associated with an increased risk of ischemic stroke, but also with increased oxidative DNA damage and brain injury after cerebral ischemia –reperfusion. However, the cellular and molecular mechanisms underlying FA deficiency-associated neuropathogenesis are not completely understood. In the present study, we tested the hypothesis that neuronal autophagy in focal cerebral ischemia rats may be involved in the mechanisms of FA deficienc y -induced injury to neuronal cells. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 6, 2016 Category: Biochemistry Authors: Yaqian Zhao, Guowei Huang, Shuang Chen, Yun Gou, Zhiping Dong, Xumei Zhang Source Type: research

Pomegranate protects against arsenic-induced p53-dependent ROS-mediated inflammation and apoptosis in liver cells
In this study we have selected a range of environmentally relevant doses of arsenic to examine the basis of arsenic toxicity and the role of pomegranate fruit extract in combating it. Male Swiss albino mice exposed to different doses of arsenic presented marked hepatic injury as evident from histological and electron microscopic studies. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 5, 2016 Category: Biochemistry Authors: Sreetama Choudhury, Sayan Ghosh, Sudeshna Mukherjee, Payal Gupta, Saurav Bhattacharya, Arghya Adhikary, Sreya Chattopadhyay Source Type: research

The proportion of total C18:1 trans fatty acids in red blood cell membranes relates to carotid plaque prevalence
Consistent evidence supports the pro-atherogenic properties of dietary trans fatty acids (TFA). However, there are no clinical data on TFA intake and atheroma plaque. We cross-sectionally investigated whether the proportion of total C18:1 TFA in red blood cells (RBC), which mirrors dietary TFA intake, independently relates to carotid plaque prevalence in subjects with new-onset type 2 diabetes mellitus without prior cardiovascular disease (n=101, 56% men, mean age 61 y) and age- and sex-matched controls (n=96). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - September 5, 2016 Category: Biochemistry Authors: Zoe Herreras, Montserrat Cof án, Marta Catalan, Carlos Calvo, Montserrat Pinyol, Antonio J. Amor, Rosa Gilabert, Emilio Ros, Aleix Sala-Vila, Emilio Ortega Source Type: research