Soy isoflavones (Glycine max) ameliorates hypertriglyceridemia and hepatic steatosis in high fat fed ovariectomised Wistar rats (An experimental model of postmenopausal obesity)

Obesity emerged as the major risk factor for metabolic syndrome. Postmenopausal women are more prone to develop obesity than premenopausal women. The absence of safe and effective conventional treatments for postmenopausal obesity has changed the focus to natural products as alternative remedy. We investigated the molecular basis of the effect of soy isoflavones on hypertriglyceridemia and hepatic steatosis in an animal model of postmenopausal obesity. Ovariectomised (OVX) and sham operated Wistar rats were fed with high fat diet (HFD) and normal diet (ND) for eight weeks with and without soy isoflavones extract (SIF, 150mg/kg BW/day).

Source: The Journal of Nutritional Biochemistry - September 7, 2016 Category: Biochemistry Authors: P. Sankar, P. Rajaa Muthu, Zachariah Bobby, Sajini Elizabeth Jacob, M.G. Sridhar Source Type: research