The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Contributions of Polyunsaturated Fatty Acids (PUFA) on Cerebral Neurobiology: An Integrated Omics Approach with Epigenomic Focus
The epigenetic landscape is vulnerable to diets. Here, we investigated the influence of different polyunsaturated fatty acids (PUFA) dietary supplements on rodents' nervous system development and functions, and potential consequences to neurodegenerative disorders. Our previous nutrigenomics study showed significant impact of high n-3 PUFA enriched diet (ERD) on synaptogenesis and various neuromodulators. The present study introduced a second equicaloric diet with n-6 PUFA balanced by n-3 PUFA (BLD). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 3, 2017 Category: Biochemistry Authors: Nabarun Chakraborty, Seid Muhie, Raina Kumar, Aarti Gautam, Seshamalini Srinivasan, Bintu Sowe, George Dimitrov, Stacy-Ann Miller, Marti Jett, Rasha Hammamieh Source Type: research

In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans
The role of inflammation and oxidative stress is critical during onset of metabolic disorders and this has been sufficiently established in literature. In the present study, we evaluated the effects of sesamol and sesamin, two important bioactive molecules present in sesame oil, on the generation of inflammatory and oxidative stress factors in LPS injected rats. Sesamol and sesamin lowered LPS induced expression of cPLA2 (61% and 56%), 5-LOX (44% and 51%), BLT-1(32% and 35%) and LTC4 synthase (49% and 50%), respectively. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 29, 2016 Category: Biochemistry Authors: P.S. Yashaswini, Bettahalli Sadashivaiah, T.R. Ramaprasad, Sridevi A. Singh Source Type: research

Reduction of Iodate in Iodated salt to Iodide during Cooking with Iodine as Measured by an Improved HPLC / ICP – MS Method
Background: Iodate is a strong oxidant, and some animal studies indicate that iodate intake may cause adverse effects. A key focus of the safety assessment of potassium iodate as a salt additive is determining whether iodate is safely reduced to iodide in food. Objective: To study the reduction of iodate in table salt to iodide and molecular iodine during cooking. Materials and Methods: Fifteen food samples cooked with and without iodated salt were prepared in duplicate. The iodine in the cooked food was extracted with deionized water. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 29, 2016 Category: Biochemistry Authors: Liejun Liu, Xiuwei Li, Haiyan Wang, Xiaoxiao Cao, Wei Ma Source Type: research

Cordycepin inhibits migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation
This study investigates the effect of cordycepin on the migration of human glioblastoma cells. Cordycepin suppressed the migration of the human glioblastoma cell lines U87MG and LN229 in transwell and wound healing assays. Cordycepin decreased protein expression of integrin α1, focal adhesion kinase (FAK), p-FAK, paxillin and p-paxillin. The lysosomal inhibitor NH4Cl blocked the ability of cordycepin to inhibit focal adhesion protein expression and glioma cell migration. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 29, 2016 Category: Biochemistry Authors: Dueng-Yuan Hueng, Ching-Hsuan Hsieh, Yu-Chen Cheng, Wen-Chiuan Tsai, Ying Chen Source Type: research

Targeted Next Generation Sequencing of the Entire Vitamin D Receptor Gene Reveals Polymorphisms Correlated with Vitamin D Deficiency among Older Filipino Women With and Without Fragility Fracture
This study aimed to discover genetic variants in the entire 101 kB vitamin D receptor (VDR) gene for vitamin D deficiency in a group of post-menopausal Filipino women using targeted next generation sequencing (TNGS) approach in a case –control study design. A total of fifty women with and without osteoporotic fracture seen at the Philippine Orthopedic Center were included. Blood samples were collected for determination of serum vitamin D, calcium, phosphorus, glucose, blood urea nitrogen, creatinine, aspartate aminotransferase, alanine aminotransferase and as primary source for targeted VDR gene sequencing using the Ion ...
Source: The Journal of Nutritional Biochemistry - December 21, 2016 Category: Biochemistry Authors: Mark Pretzel Zumaraga, Paul Julius Medina, Juan Miguel Recto, Lauro Abrahan, Edelyn Azurin, Celeste C. Tanchoco, Cecilia A. Jimeno, Cynthia Palmes-Saloma Source Type: research

Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics
This study considered the physiological modulation of liver proteins due to the supplementation with fish oils under two different dietary backgrounds: standard or high in fat and sucrose diets, and their combination with grape polyphenols which provide reducing power. By using a quantitative proteomics approach based on isobaric tags for relative and absolute quantitation (iTRAQ) complemented with 2D –DIGE analysis, we showed that the capacity of fish oils, polyphenols or both for regulating liver proteins depends on the dietary context. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 20, 2016 Category: Biochemistry Authors: Luc ía Méndez, Sergio Ciordia, María Soledad Fernández, Silvia Juárez, Antonio Ramos, Manuel Pazos, José M. Gallardo, Josep Lluís Torres, M. Rosa Nogués, Isabel Medina Source Type: research

Green Tea Extract Treatment Reduces NF κB Activation In Mice With Diet-Induced Nonalcoholic Steatohepatitis By Lowering TNFR1 And TLR4 Expression And Ligand Availability
NF κB-mediated inflammation contributes to liver injury during nonalcoholic steatohepatitis (NASH). We hypothesized that antiinflammatory activities of green tea extract (GTE) during NASH would lower tumor necrosis factor receptor-1 (TNFR1)- and Toll-like receptor-4 (TLR4)-mediated NFκB activation. M ale C57BL/6 J mice (6 wk. old) were fed a low-fat (LF) or high-fat (HF) diet for 12 wk. to induce NASH. They were then randomized to continue on these diets supplemented with 0 or 2% GTE (n=10/group) for an additional 8 wk. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 20, 2016 Category: Biochemistry Authors: Jinhui Li, Teryn N. Sapper, Eunice Mah, Meredith V. Moller, Joshua B. Kim, Chureeporn Chitchumroonchokchai, Joshua D. McDonald, Richard S. Bruno Source Type: research

EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down regulation of NF- κB and MMP-9
Epigallocatechin-3-gallate (EGCG), the bioactive polyphenol in green tea, has been demonstrated to have various biological activities. Our study aims to investigate the anti-proliferation and anti-migration effects of EGCG against bladder cancer SW780 cells both in vitro and in vivo. Our results showed that treatment of EGCG resulted in significant inhibition of cell proliferation by induction of apoptosis, without obvious toxicity to normal bladder epithelium SV-HUC-1 cells. EGCG also inhibited SW780 cell migration and invasion at 25 –100 μM. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 18, 2016 Category: Biochemistry Authors: Ke-Wang Luo, Wei-Chen, Wing-Yin Lung, Xia-Yun Wei, Bao-Hui Cheng, Zhi-Ming Cai, Wei-Ren Huang Source Type: research

Transcriptional response of skeletal muscle to a low-protein perinatal diet in rat offspring at different ages: the role of key enzymes of glucose-fatty acid oxidation
This study evaluated gene and protein expression of key-enzymes of glycolytic pathway (HK2, PFK, PDK4 and CS), and fatty acid oxidation (CPT1 and β-HAD) of two different types of skeletal muscle (soleus and extensor digitorium longus (EDL) from offspring rats at 30 and 90 days of age, exposed to maternal isoenergetic low-protein diet throughout gestation and lactation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 13, 2016 Category: Biochemistry Authors: Jos é Luiz de Brito Alves, Ana Elisa Toscano, João Henrique da Costa-Silva, Hubert Vidal, Carol Góis Leandro, Luciano Pirola Source Type: research

Physiological effects of γ-linolenic acid and sesamin on hepatic fatty acid synthesis and oxidation
Interrelated effects of γ-linolenic acid (GLA) and sesamin, a sesame lignan, on hepatic fatty acid synthesis and oxidation were examined.Rats were fed experimental diets supplemented with 0 or 2 g/kg sesamin (1:1 mixture of sesamin and episesamin), and containing 100 g/kg of either palm oil (saturated fat), safflower oil rich in linoleic acid or oil of evening primrose origin containing 43% GLA (GLA oil) for 18 d.In rats fed sesamin-free diets, GLA oil, compared with other oils, increased the activity and mRNA levels of various enzymes involved in fatty acid oxidation, except for some instances. (Source: The Journal of Nu...
Source: The Journal of Nutritional Biochemistry - December 12, 2016 Category: Biochemistry Authors: Takashi Ide, Haruka Iwase, Saaya Amano, Saki Sunahara, Ayuka Tachihara, Minako Yagi, Tsuyoshi Watanabe Source Type: research

Effect of high fructose intake on the development of hypertension in the spontaneously hypertensive rats: The role of AT1R/gp91PHOX signaling in the rostral ventrolateral medulla
Both genetic and dietary factors determine the development of hypertension. Whether dietary factor impacts the development of hereditary hypertension is unknown. Here, we evaluated the effect of daily high fructose diet (HFD) on the development of hypertension in adolescent spontaneously hypertensive rat (SHR). Six week-old SHR were randomly divided into two groups to receive HFD or normal diet (ND) for 3 weeks. The temporal profile of systolic blood pressure (SBP), alongside the sympathetic vasomotor activity, in the SHR-HFD showed significantly greater increases at 9 –12 weeks of age compared with the age-matched SHR-N...
Source: The Journal of Nutritional Biochemistry - December 2, 2016 Category: Biochemistry Authors: Kay L.H. Wu, Chih-Wei Wu, You-Lin Tain, Yung-Mei Chao, Chun-Ying Hung, Pei-Chia Tsai, Wei-Sing Wong, Cheng-Dean Shih Source Type: research

Modulation of Urinary Siderophores by the Diet, Gut Microbiota and Inflammation in Mice
In this study, we have employed Chrome Azurol S (CAS) assay which is a well-established method for bacterial siderophores study, to detect and quantify mammalian siderophores in urine samples. Our study demonstrates that siderophores in urine can be altered by diet, gut microbiota and inflammation. C57BL/6 mice, fed on plant-based chow diets which contain numerous phytochemicals, have more siderophores in the urine compared to those fed on purified diets. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 1, 2016 Category: Biochemistry Authors: Xia Xiao, Beng San Yeoh, Piu Saha, Yuan Tian, Vishal Singh, Andrew D. Patterson, Matam Vijay-Kumar Source Type: research

Downregulation of fibroblast growth factor 2 and its co-receptors heparan sulfate proteoglycans by resveratrol underlies the improvement of cardiac dysfunction in experimental diabetes
Cardiac remodeling in diabetes involves cardiac hypertrophy and fibrosis and fibroblast growth factor 2 (FGF2) is an important mediator of this process. Resveratrol, a polyphenolic antioxidant, reportedly promotes the improvement of cardiac dysfunction in diabetic rats. However, little information exists linking the amelioration of the cardiac function promoted by resveratrol and the expression of FGF2 and its co-receptors, heparan sulfate proteoglycans (HSPGs: Glypican-1 and Syndecan-4), in cardiac muscle of type 2 diabetic rats. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - December 1, 2016 Category: Biochemistry Authors: C élia Maria Cássaro Strunz, Alessandra Roggerio, Paula Lázara Cruz, Ana Paula Pacanaro, Vera Maria Cury Salemi, Luiz Alberto, Antonio de Pádua Mansur, Maria Cláudia Irigoyen Source Type: research

1 α,25-Dihydroxyvitamin D Inhibits de novo Fatty Acid Synthesis and Lipid Accumulation in Metastatic Breast Cancer Cells through Downregulation of Pyruvate Carboxylase
Both increased de novo fatty acid synthesis and higher neutral lipid accumulation are a common phenotype observed in aggressive breast cancer cells, making lipid metabolism a promising target for breast cancer prevention. In the present studies we demonstrate a novel effect of the active metabolite of vitamin D, 1 α,25-dihydroxyvitamin D (1,25(OH)₂D) on lipid metabolism in malignant breast epithelial cells. Treatment of MCF10CA1a breast epithelial cells with 1,25(OH)₂D (10 nM) for five and seven days decreased the level of triacylglycerol, the most abundant form of neutral lipids, by 20%(±3.9) and 50%(± 5.9), respec...
Source: The Journal of Nutritional Biochemistry - December 1, 2016 Category: Biochemistry Authors: Tomasz Wilmanski, Kimberly Buhman, Shawn S. Donkin, John R. Burgess, Dorothy Teegarden Source Type: research

Plant flavonoids in cancer chemoprevention: Role in genome stability
Carcinogenesis is a multistage process that involves a series of events comprising of genetic and epigenetic changes leading to the initiation, promotion, and progression of cancer. Chemoprevention is referred to as the use of nontoxic natural compounds, synthetic chemicals or their combinations to intervene in multistage carcinogenesis. Chemoprevention through diet modification, i.e. increased consumption of plant-based food, has emerged as a most promising and potentially cost-effective approach to reducing the risk of cancer. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - November 27, 2016 Category: Biochemistry Authors: Vazhappilly Cijo George, Graham Dellaire, H.P. Vasantha Rupasinghe Tags: REVIEWS: CURRENT TOPICS Source Type: research