Impact of High Fat Diet on the Proteome of Mouse Liver
Chronic over-nutrition, for instance high fat diet (HFD) feeding, is a major cause of rapidly growing incidence of metabolic syndromes. However, the mechanisms underlying HFD induced adverse effects on human health are not clearly understood. HFD-fed C57BL6/J mouse has been a popular model employed to investigate the mechanisms. Yet, there is no systematic and comprehensive study of the impact of HFD on the protein profiles of the animal. Here, we present a proteome-wide study of the consequences of long-term HFD feeding. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 25, 2016 Category: Biochemistry Authors: Outhiriaradjou Benard, Jihyeon Lim, Pasha Apontes, Xiaohong Jing, Ruth H. Angeletti, Yuling Chi Source Type: research

Alcohol-free fermented blueberry-blackberry beverage phenolic extract attenuates diet-induced obesity and blood glucose in C57BL/6J mice
The aim of this study was to determine the potential of phenolic compounds from a fermented blackberry-blueberry beverage to reduce diet-induced obesity and hyperglycemia in mice fed a 60% high fat diet (HFD) for ten weeks after one week of pre-treatment. C57BL/6j mice were randomized into six groups and allowed to drink (ad libitum) an alcohol-free blackberry-blueberry beverage (AFFB, 8.4 mg ANC/kg BW/d), three doses of a phenolic extract (PAE) from AFFB at 0.1X, 1X and 2X anthocyanin (ANC) concentrations, sitagliptin (hypoglycemic positive control), or water (negative control). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 25, 2016 Category: Biochemistry Authors: Michelle H. Johnson, Matthew Wallig, Diego A. Luna Vital, Elvira G. de Mejia Source Type: research

Oral Supplementation of 2’-fucosyllactose during lactation improves memory and learning in rats
Human milk oligosaccharides (HMOs) have been proposed to exert beneficial effects on brain development. During the last decades, most of the studies have focused on the evaluation of sialylated structures but recent experiments have also tested fucosylated oligosaccharides, i.e. 2’- fucosyllactose (2’-FL). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 25, 2016 Category: Biochemistry Authors: Elena Oliveros, María Ramirez, Enrique Vazquez, Alejandro Barranco, Agnes Gruart, Jose Maria Delgado-Garcia, Rachael Buck, Ricardo Rueda, Maria J. Martin Source Type: research

Mechanisms by which Cocoa Flavanols Improve Metabolic Syndrome and Related Disorders
Dietary administration of cocoa flavanols may be an effective complementary strategy for alleviation or prevention of metabolic syndrome, particularly glucose intolerance. The complex flavanol composition of cocoa provides the ability to interact with a variety of molecules, thus allowing numerous opportunities to ameliorate metabolic diseases. These interactions likely occur primarily in the gastrointestinal tract, where native cocoa flavanol concentration is high. Flavanols may antagonize digestive enzymes and glucose transporters, causing a reduction in glucose excursion, which helps patients with metabolic disorders ma...
Source: The Journal of Nutritional Biochemistry - January 23, 2016 Category: Biochemistry Authors: Karen M. Strat, Thomas J. Rowley, Andrew T. Smithson, Jeffery S. Tessem, Matthew W. Hulver, Dongmin Liu, Brenda M. Davy, Kevin P. Davy, Andrew P. Neilson Source Type: research

Early intake of long chain polyunsaturated fatty acids preserve brain structure and function in diet induced obesity
Worldwide, the incidence of obesity is increasing at an alarming rate, and the number of children with obesity is especially worrisome. These developments raise concerns about the physical, psychosocial and cognitive consequences of obesity. It was shown that early dietary intake of arachidonic acid (ARA) and docosahexaenoic acid (DHA) can reduce the detrimental effects of later obesogenic feeding on lipid metabolism and adipogenesis in an animal model of mild obesity. In the present study, the effects of early dietary ARA and DHA on cognition and brain structure were examined in mildly obesogenic ApoE*3Leiden mouse model....
Source: The Journal of Nutritional Biochemistry - January 20, 2016 Category: Biochemistry Authors: Ilse A.C. Arnoldussen, Valerio Zerbi, Maximilian Wiesmann, Rikko H.J. Noordman, Simone Bolijn, Martina P.C. Mutsaers, Pieter J.W.C. Dederen, Robert Kleemann, Teake Kooistra, Eric A.F. van Tol, Gabriele Gross, Marieke H. Schoemaker, Peter Y. Wielinga, Aman Source Type: research