Early intake of long chain polyunsaturated fatty acids preserve brain structure and function in diet induced obesity

Worldwide, the incidence of obesity is increasing at an alarming rate, and the number of children with obesity is especially worrisome. These developments raise concerns about the physical, psychosocial and cognitive consequences of obesity. It was shown that early dietary intake of arachidonic acid (ARA) and docosahexaenoic acid (DHA) can reduce the detrimental effects of later obesogenic feeding on lipid metabolism and adipogenesis in an animal model of mild obesity. In the present study, the effects of early dietary ARA and DHA on cognition and brain structure were examined in mildly obesogenic ApoE*3Leiden mouse model.

Source: The Journal of Nutritional Biochemistry - January 20, 2016 Category: Biochemistry Authors: Ilse A.C. Arnoldussen, Valerio Zerbi, Maximilian Wiesmann, Rikko H.J. Noordman, Simone Bolijn, Martina P.C. Mutsaers, Pieter J.W.C. Dederen, Robert Kleemann, Teake Kooistra, Eric A.F. van Tol, Gabriele Gross, Marieke H. Schoemaker, Peter Y. Wielinga, Aman Source Type: research