The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Liquid Fructose In Western Diet-Fed Mice Impairs Liver Insulin Signaling And Causes Cholesterol And Triglyceride Loading Without Changing Calorie Intake And Body Weight
Liquid-fructose associates with prevalence of T2DM and obesity. Intervention studies suggest that metabolically unfit individuals are more responsive than healthy individuals to liquid-fructose. We determined whether mice consuming an obesogenic Western-diet were more responsive than chow-fed mice to the alterations induced by liquid fructose-supplementation (LFS). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - November 1, 2016 Category: Biochemistry Authors: Miguel Baena, Gemma Sang üesa, Natalia Hutter, José María Beltrán, Rosa María Sánchez, Núria Roglans, Marta Alegret, Juan Carlos Laguna Source Type: research

Physiological Effects of Epigallocatechin-3-gallate (EGCG) on Energy Expenditure for Prospective Fat Oxidation in Humans: A Systematic Review and Meta-analysis
Green tea catechins (GTCs) are known to improve fat oxidation during fasted, rested and exercise conditions wherein epigallocatechin-3-gallate (EGCG) is thought to be the most pharmacologically active and has been studied extensively. From the available data of randomized controlled trials (RCTs) on EGCG, we carried out a systematic review and meta-analysis to elucidate whether EGCG consumption indeed increase energy expenditure and promote fat oxidation. A systematic review of the literature was conducted using electronic databases (PubMed, Embase, Cochrane Library, CINAHL, JICST, JSTPLUS, and JMEDPLUS and others) and 8 R...
Source: The Journal of Nutritional Biochemistry - November 1, 2016 Category: Biochemistry Authors: Mahendra P. Kapoor, Masaaki Sugita, Yoshitaka Fukuzawa, Tsutomu Okubo Source Type: research

Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet
FGF21 (fibroblast growth factor 21) exhibits a circadian oscillation and its induction is critical during fasting. When secreted by liver and skeletal muscle, FGF21 enhances thermogenic activity in brown adipose tissue (BAT) by utilizing uncoupling protein 1 (UCP1) to dissipate energy as heat. Recently, it has been reported that UCP1 is not required for FGF21-mediated reduction in body weight or improvements in glucose homeostasis. As the relationship between FGF21 and UCP1 induction in tissues other than BAT is less clear, we tested the effect of restricted feeding (RF) and high dietary fat on FGF21 circadian expression a...
Source: The Journal of Nutritional Biochemistry - November 1, 2016 Category: Biochemistry Authors: Nava Chapnik, Yoni Genzer, Oren Froy Source Type: research

Dietary glutamine supplementation enhances endothelial progenitor cell mobilization in streptozotocin-induced diabetic mice subjected to limb ischemia
This study investigated the effects of oral glutamine (GLN) supplementation on circulating EPC mobilization and expression of tissue EPC-releasing markers in diabetic mice subjected to limb ischemia. Diabetes was induced by a daily intraperitoneal injection of streptozotocin for 5 days. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 28, 2016 Category: Biochemistry Authors: Shiau-Tsz Su, Chiu-Li Yeh, Yu-Chen Hou, Man-Hui Pai, Sung-Ling Yeh Source Type: research

Antioxidant properties of tea blunt ROS-dependent lipogenesis: beneficial effect on hepatic steatosis in a high fat-high sucrose diet NAFLD obese rat model
Oxidative stress could trigger lipid accumulation in liver and thus hepatic steatosis. Tea is able to prevent liver disorders but a direct link between antioxidant capacities and prevention of steatosis has not been reported yet. We aimed to investigate such relationship in a rat model of high fat-high sucrose diet (HFS)-induced obesity and to explore more deeply the mechanisms in isolated hepatocytes. Wistar rats were divided into a Control group (standard diet), a HFS group (high fat-sucrose diet) and a HFS+Tea group (HFS diet with ad-libitum access to tea drink). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 28, 2016 Category: Biochemistry Authors: Laura Braud, Sylvain Battault, Gr égory Meyer, Alessandro Nascimento, Sandrine Gaillard, Georges de Sousa, Roger Rahmani, Catherine Riva, Martine Armand, Jean-Michel Maixent, Cyril Reboul Source Type: research

Preventive effects of Goji berry on dextran sulfate sodium induced colitis in mice
Goji berry (Lycium barbarum) exerts immune modulation and suppresses inflammation in vitro and in vivo. We hypothesized that Goji berry had the beneficial effects on dextran sulfate sodium (DSS) induced colitis in C57BL/6 mice through suppressing inflammation. 6-week old male C57BL/6 mice were supplemented with a standard AIN-93G diet with or without 1% (w/w) Goji berry for 4 weeks. Then, colitis was induced by supplementing 3% DSS in drinking water for 7 days, followed by 7 days of remission period to mimic ulcerative colitis (UC) symptoms. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 26, 2016 Category: Biochemistry Authors: Yifei Kang, Yansong Xue, Min Du, Mei-Jun Zhu Source Type: research

Suppression of TNF- α and free radicals reduces systematic inflammatory and metabolic disorders: radioprotective effects of ginseng oligopeptides on intestinal barrier function and antioxidant defense
This study was aimed to investigate the effects of ginseng (Panax ginseng C. A. Mey.) oligopeptides (GOP) on irradiation-induced intestinal injury and antioxidant defense in mice. BALB/c mice (8 weeks old) were randomly divided into six groups: vehicle control, irradiation control (IR), IR+Whey protein (0.30 g/kg BW), IR+GOP 0.15 g/kg BW, IR+GOP 0.30 g/kg BW, and IR+GOP 0.60 g/kg BW. Post-irradiation 30-day-survival trial, white blood cells count and bone marrow hematopoietic system damage were performed to identify the injury degree induced by irradiation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 25, 2016 Category: Biochemistry Authors: Li-Xia He, Jun-Bo Wang, Bin Sun, Jian Zhao, Lin Li, Teng Xu, Hui Li, Jing-Qin Sun, Jinwei Ren, Rui Liu, Qi-He Chen, Zhao-Feng Zhang, Yong Li Source Type: research

Increasing cAMP levels of preadipocytes by cyanidin-3-glucoside treatment induces the formation of beige phenotypes in 3 T3-L1 adipocytes
Obesity is a serious health problem and a major risk factor for the onset of several diseases such as heart disease, diabetes, stroke, and cancer. The conversion of white adipocytes to brown-like adipocytes, also called beige or brite adipocytes, by pharmacological and dietary compounds has gained attention as an effective treatment for obesity. Cyanidin-3-glucoside (Cy3G), a polyphenolic compound contained in black soybean, blueberry and grape, has several anti-obesity effects. However, there are no reports on the role of Cy3G in the induction of differentiation of preadipocytes to beige adipocytes and corresponding pheno...
Source: The Journal of Nutritional Biochemistry - October 24, 2016 Category: Biochemistry Authors: Toshiya Matsukawa, Myra O. Villareal, Hideko Motojima, Hiroko Isoda Source Type: research

A diet induced Sprague –Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis
This study aimed to establish a reliable dietary model of NASH-related cirrhosis in a relatively short period. Male Sprague –Dawley rats (9 weeks of age) were randomly assigned to normal, high-fat (HF), or two types (1.25% or 2.5% cholesterol) of high-fat and high-cholesterol (HFC) diets for 18 weeks. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 23, 2016 Category: Biochemistry Authors: Mayuko Ichimura, Miki Masuzumi, Miku Kawase, Mika Sakaki, Shizuka Tamaru, Yasuo Nagata, Kazunari Tanaka, Kazuhito Suruga, Koichi Tsuneyama, Satoru Matsuda, Katsuhisa Omagari Source Type: research

Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high fat diet-induced obese mice
Western-type diets can induce obesity and related conditions such as dyslipidemia, insulin resistance, and hepatic steatosis. We evaluated the effects of milk sphingomyelin (SM) and egg SM on diet-induced obesity, the development of hepatic steatosis, and adipose inflammation in C57BL/6 J mice fed a high fat, cholesterol-enriched diet for 10 weeks. Mice were fed either a low fat diet (10% kcal from fat) (LFD, n=10), a high fat diet (60% kcal from fat) (HFD, n=14), or a high fat diet modified to contain either 0.1% (w/w) milk SM (HFMSM, n=14) or 0.1% (w/w) egg SM (HFESM, n=14). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 23, 2016 Category: Biochemistry Authors: Gregory H. Norris, Caitlin M. Porter, Christina Jiang, Courtney L. Millar, Christopher N. Blesso Source Type: research

Metabolic Outcomes of Bergamot Polyphenolic Fraction Administration in Patients Treated with Second-Generation Antipsychotics: a Pilot Study
Second-generation antipsychotics (SGAs) are notoriously associated with a marked increase in body weight and with a wide range of metabolic adverse effects, and their chronic use is related with an increased risk for the development of metabolic syndrome (MS). Different adjunctive treatments have been proposed to reduce SGAs-induced weight gain and/or metabolic abnormalities with inconsistent or too limited evidence to support their regular clinical use, thus suggesting the need to find new possible treatments. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 21, 2016 Category: Biochemistry Authors: Antonio Bruno, Gianluca Pandolfo, Manuela Crucitti, Antonino Maisano, Rocco A. Zoccali, Maria Rosaria Anna Muscatello Source Type: research

Intermittent fasting reduces body fat but exacerbates hepatic insulin resistance in young rats regardless of high protein and fat diets
Intermittent fasting (IMF) is a relatively new dietary approach to weight management although the efficacy and adverse effects have not been full elucidated and the optimal diets for IMF are unknown. We tested the hypothesis that a one-meal-per-day intermittent fasting with high fat (HF) or protein (HP) diets can modify energy, lipid, and glucose metabolism in normal young male Sprague –Dawley rats with diet-induced obesity or overweight. Male rats aged 5 weeks received either HF (40% fat) or HP (26% protein) diets ad libitum (AL) or for 3 h at the beginning of the dark cycle (IMF) for 5 weeks. (Source: The Journal of Nu...
Source: The Journal of Nutritional Biochemistry - October 14, 2016 Category: Biochemistry Authors: Sunmin Park, Kyung Min Yoo, Joo Suk Hyun, Suna Kang Source Type: research

Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle
Epidemiological studies show a dose-dependent relationship between green tea consumption and reduced risk for type 2 diabetes and cardiovascular disease. Bioactive compounds in green tea including the polyphenol epigallocatechin 3-gallate (EGCG) have insulin-mimetic actions on glucose metabolism and vascular function in isolated cell culture studies. The aim of this study is to explore acute vascular and metabolic actions of EGCG in skeletal muscle of Sprague –Dawley rats. Direct vascular and metabolic actions of EGCG were investigated using surgically isolated constant-flow perfused rat hindlimbs. (Source: The Journal o...
Source: The Journal of Nutritional Biochemistry - October 13, 2016 Category: Biochemistry Authors: Huei L.H. Ng, Dino Premilovac, Stephen Rattigan, Stephen M. Richards, Ranganath Muniyappa, Michael J. Quon, Michelle A. Keske Source Type: research

Comparative Proteomic Analyses of the Parietal Lobe from Rhesus Monkeys Fed a High Fat/Sugar Diet with and without Resveratrol Supplementation, Relative to a Healthy Diet: Insights into the Roles of Unhealthy Diets and Resveratrol on Function
A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling fo...
Source: The Journal of Nutritional Biochemistry - October 12, 2016 Category: Biochemistry Authors: Aaron M. Swomley, Judy C. Triplett, Jeriel T. Keeney, Govind Warrier, Kevin J. Pearson, Julie A. Mattison, Rafael de Cabo, Jian Cai, Jon B. Klein, D. Allan Butterfield Source Type: research

Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation
In this study, we examined whether the prevention effects of SFN in lipopolysaccharide (LPS)-induced depression-like behavior mice. Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor- α (TNF-α) level, and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - October 10, 2016 Category: Biochemistry Authors: Ji-chun Zhang, Wei Yao, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Jin Wu, Yusuke Ushida, Hiroyuki Suganuma, Kenji Hashimoto Source Type: research