The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Aberrant expression of microRNA induced by high fructose diet: Implications in the pathogenesis of hyperlipidemia and hepatic insulin resistance
Fructose is a highly lipogenic sugar which can alter energy metabolism and trigger metabolic disorders. In the current study, microRNAs (miRNAs) altered by a high-fructose diet were comprehensively explored to elucidate their significance in the pathogenesis of chronic metabolic disorders. miRNA expression profiling using small non-coding RNA sequencing revealed that 19 miRNAs were significantly upregulated and 26 were downregulated in the livers of high-fructose-fed mice compared to chow-fed mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 17, 2017 Category: Biochemistry Authors: Neetu Sud, Hanyuan Zhang, Kaichao Pan, Xiao Cheng, Juan Cui, Qiaozhu Su Source Type: research

Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model
The high prevalence of zinc deficiency is a global public health concern, and suboptimal maternal zinc consumption has been associated with adverse effects ranging from impaired glucose tolerance to low birthweights. The mechanisms that contribute to altered development and poor health in zinc deficient offspring are not completely understood. To address this gap, we utilized the Danio rerio model and investigated the impact of dietary zinc deficiency on adults and their developing progeny. Zinc deficient adult fish were significantly smaller in size, and had decreases in learning and fitness. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 17, 2017 Category: Biochemistry Authors: Laura M. Beaver, Yasmeen M. Nkrumah-Elie, Lisa Truong, Carrie L. Barton, Andrea L. Knecht, Greg D. Gonnerman, Carmen P. Wong, Robert L. Tanguay, Emily Ho Source Type: research

Biallelic and triallelic approaches of 5-HTTLPR polymorphism are associated with food intake and nutritional status in childhood
The 5-HTT gene contains polymorphisms in its promoter region, the insertion/deletion (5-HTTLPR) that creates long (L) or short (S) alleles (biallelic approach) and SNP (rs25531) in L allele (triallelic approach). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 10, 2017 Category: Biochemistry Authors: Raquel C K Miranda, J úlia P Genro, Paula D B Campagnolo, Vanessa S Mattevi, Márcia R Vitolo, Silvana Almeida Source Type: research

Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating Sirt1-AMPK pathway
Polysaccharide from Angelica sinensis (Oliv.) Diels (ASP), possesses many bioactivities, such as hematopoiesis, anti-inflammation, anti-oxidation and metabolism regulation. The aim of this study was to investigate the mechanisms underlying the protection of a combination of high-fat diet and streptozotocin-induced liver damage in diabetic Balb/c mice by ASP. Results showed that ASP had beneficial effects on ameliorating hyperglycemia, dyslipidemia and liver injury. Moreover, mechanistic study for the liver-protective role in vivo demonstrated that ASP enhanced the activities of SOD and GPX and increased the GSH content, wh...
Source: The Journal of Nutritional Biochemistry - February 9, 2017 Category: Biochemistry Authors: Kaiping Wang, Zhuohong Tang, Jinglin Wang, Peng Cao, Qiang Li, Weizhi Shui, Hongjing Wang, Ziming Zheng, Yu Zhang Source Type: research

Dietary lipids differentially modulate the initiation of experimental breast carcinogenesis through their influence on hepatic xenobiotic metabolism and DNA damage in the mammary gland
Breast cancer is the most common malignancy among women worldwide. In addition to reproductive factors, environmental factors such as nutrition and xenobiotic exposure have a role in the etiology of this malignancy. A stimulating and a potentially protective effect on experimental breast cancer has been previously described for high corn oil and high extra-virgin olive oil diets, respectively. This work investigates the effect of these lipids on the metabolism of 7,12-dimethylbenz(a)anthracene (DMBA), a polycyclic aromatic hydrocarbon that can initiate carcinogenesis, and its consequences in an experimental rat breast canc...
Source: The Journal of Nutritional Biochemistry - February 9, 2017 Category: Biochemistry Authors: Miguel Ángel Manzanares, Cristina de Miguel, M. Carme Ruiz de Villa, Regina M. Santella, Eduard Escrich, Montserrat Solanas Source Type: research

Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring
Importance of calcium and vitamin D deficiency is well established in adult dyslipidemia. We hypothesized that maternal calcium and vitamin D deficiency could alter offspring's lipid metabolism. Our objective was to investigate the effect of maternal dietary calcium and vitamin D deficiency on lipid metabolism and liver function of the F1 generation offspring. intergenerational calcium-deficient (CaD) and vitamin D-deficient (VDD) models were developed by mating normal male rats with deficient females and continuing maternal-deficient diets through pregnancy and lactation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 8, 2017 Category: Biochemistry Authors: Sona S. Sharma, Nivedita M. Jangale, Abhay M. Harsulkar, Medha K. Gokhale, Bimba N. Joshi Tags: Research Article Source Type: research

Chronic maternal calcium and 25-hydroxy vitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring
Importance of calcium and vitamin D deficiency is well established in adult dyslipidemia. We hypothesized that maternal calcium and vitamin D deficiency could alter offspring's lipid metabolism. Our objective was to investigate the effect of maternal dietary calcium and vitamin D deficiency on lipid metabolism and liver function of the F1 generation offspring. Inter-generational calcium deficient (CaD) and vitamin D deficient (VDD) models were developed by mating normal male rats with deficient females and continuing maternal deficient diets through pregnancy and lactation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 7, 2017 Category: Biochemistry Authors: Sona S. Sharma, Nivedita M. Jangale, Abhay M. Harsulkar, Medha K. Gokhale, Bimba N. Joshi Source Type: research

Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells
Zinc plays an important role in maintaining intestinal barrier function, as well as modulating cellular signaling recognition and protein kinase activities. The phosphatidylinositol 3-kinase (PI3K) cascade has been demonstrated to affect intercellular integrity and tight junction (TJ) proteins. The current study investigated the hypothesis that zinc regulates intestinal intercellular junction integrity through the PI3K/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. A transwell model of Caco-2 cell was incubated with 0, 50, 100 μM of zinc at various time points. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 29, 2017 Category: Biochemistry Authors: Yuxin Shao, Patricia G. Wolf, Shuangshuang Guo, Yuming Guo, H. Rex Gaskins, Bingkun Zhang Source Type: research

A food-based approach that targets interleukin-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis
Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic cell proliferation and chronic inflammation in an HCD-consuming human-relevant pig model. We observed elevated colonic mucosal interleukin-6 (IL-6) expression in HCD-consuming pigs compared to standard diet controls (SD, P=.04), and IL-6 strongly correlated with Ki-67 proliferative index and zone, early biomarkers of colon cancer risk (r=0.604 and 0.743 and P=.017 and .002, res...
Source: The Journal of Nutritional Biochemistry - January 28, 2017 Category: Biochemistry Authors: Abigail Sido, Sridhar Radhakrishnan, Sung Woo Kim, Elisabeth Eriksson, Frank Shen, Qunhua Li, Vadiraja Bhat, Lavanya Reddivari, Jairam K.P. Vanamala Tags: Research article Source Type: research

N-3 polyunsaturated fatty acids alleviate high glucose-mediated dysfunction of endothelial progenitor cells and prevent ischemic injuries both in vitro and in vivo
Hyperglycemia is associated with a reduced number of endothelial progenitor cells (EPCs) that impairs vascular function. Circulating EPCs play important roles in postnatal neovasculogenesis and the prevention of ischemic injury. Frequent consumption of fish oil (FO) that is abundant with eicosapentaenoic acid (EPA) /docosahexaenoic acid (DHA) is reportedly associated with an alleviation of diabetic complications and a lowered incidence of cardiovascular disease (CVD). The aim of this study was to examine whether N-3 polyunsaturated fatty acids (PUFAs) such as EPA and DHA would reverse the high glucose-mediated dysfunction ...
Source: The Journal of Nutritional Biochemistry - January 27, 2017 Category: Biochemistry Authors: Shao-Chih Chiu, Che-Yi Chao, En-Pei Isabel Chiang, Jia-Ning Syu, Raymond L. Rodriguez, Feng-Yao Tang Source Type: research

Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver
The overconsumption of both saturated fats and fructose in the modern society has been related to the development of non-alcoholic fatty liver disease (NAFLD). However, the specific contribution of individual dietary components on the progression of NAFLD to non-alcoholic steatoepatitis (NASH) has been poorly investigated.Therefore, the aim of our study was to investigate the dissimilar effects of these two dietary components on selected proinflammatory and antioxidant pathways in the liver of C57BL/6 mice fed a standard (SD), a 45% saturated fat (HFAT), or a 60% fructose (HFRT) diet for 12 weeks. (Source: The Journal of N...
Source: The Journal of Nutritional Biochemistry - January 27, 2017 Category: Biochemistry Authors: D Nigro, F Menotti, A Cento, L Serpe, F Chiazza, F Dal Bello, F Romaniello, C Medana, M Collino, M Aragno, R Mastrocola Source Type: research

A food-based approach that targets IL-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis
Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic cell proliferation and chronic inflammation in a HCD-consuming human-relevant pig model. We observed elevated colonic mucosal IL-6 expression in HCD-consuming pigs compared to standard diet controls (SD, P=.04) and IL-6 strongly correlated with Ki-67 proliferative index and zone, early biomarkers of colon cancer risk (r=0.604, 0.743; P=.017, 0.002; respectively). (Source: The J...
Source: The Journal of Nutritional Biochemistry - January 27, 2017 Category: Biochemistry Authors: Abigail Sido, Sridhar Radhakrishnan, Sung Woo Kim, Elisabeth Eriksson, Frank Shen, Qunhua Li, Vadiraja Bhat, Lavanya Reddivari, Jairam K.P. Vanamala Source Type: research

A Combination of Dietary N-3 Fatty Acids and a Cyclooxygenase-1 Inhibitor Attenuates Non-alcoholic Fatty Liver Disease in Mice
We sought to determine whether a combination of purified n-3 fatty acids (n-3) and SC-560 (SC), a COX-1 specific inhibitor, is effective in ameliorating nonalcoholic fatty liver disease in obesity. Female WT mice were fed a high fat and high cholesterol diet (HF) supplemented with n-3 in the presence or absence of SC. Mice treated with SC alone exhibited no change in liver lipids, whereas n-3-fed mice tended to have lower hepatic lipids. Mice given n-3+SC had significantly lower liver lipids compared with HF controls indicating enhanced lipid clearance. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 25, 2017 Category: Biochemistry Authors: Viswanathan Saraswathi, Curtis Perriotte-Olson, Murali Ganesan, Cyrus V. Desouza, Yazen Alnouti, Michael J Duryee, Geoffrey M Thiele, Tara M Nordgren, Dahn L Clemens Source Type: research

Low Glycemic Load diets protect against Metabolic Syndrome and Type 2 Diabetes Mellitus in the male Nile rat
Dietary modification helps prevent and manage Metabolic Syndrome (MetS) and Type 2 Diabetes Mellitus (T2DM) in humans and Nile rats. Specifically fibrous legumes, like lentils, benefit humans, but whether this reflects a specific change in the Glycemic Load (GLoad) remains controversial. Accordingly, low-GLoad foods were tested in the glucose-sensitive Nile rat. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 25, 2017 Category: Biochemistry Authors: Julia Bolsinger, Michelle Landstrom, Andrzej Pronczuk, Andrew Auerbach, KC Hayes Source Type: research

Dietary flavonoids and modulation of natural killer cells: Implications in malignant and viral diseases
Flavonoids are a large group of secondary plant metabolites present in the diet with numerous potentially health-beneficial biological activities. In addition to antioxidant, anti-inflammatory, cholesterol-lowering, and many other biological functions reported in the literature, flavonoids appear to inhibit cancer cell proliferation and stimulate immune function. Although the immunomodulatory potential of flavonoids has been intensively investigated, only little is known about their impact on natural killer (NK) cells. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 23, 2017 Category: Biochemistry Authors: Markus Burkard, Christian Leischner, Ulrich M. Lauer, Christian Busch, Sascha Venturelli, Jan Frank Source Type: research