Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating Sirt1-AMPK pathway

Polysaccharide from Angelica sinensis (Oliv.) Diels (ASP), possesses many bioactivities, such as hematopoiesis, anti-inflammation, anti-oxidation and metabolism regulation. The aim of this study was to investigate the mechanisms underlying the protection of a combination of high-fat diet and streptozotocin-induced liver damage in diabetic Balb/c mice by ASP. Results showed that ASP had beneficial effects on ameliorating hyperglycemia, dyslipidemia and liver injury. Moreover, mechanistic study for the liver-protective role in vivo demonstrated that ASP enhanced the activities of SOD and GPX and increased the GSH content, which resulted in the reduction of hepatic ROS and MDA, and reduced the protein expression levels of liver IKK α/NF-κB/p-IκBα and the concentrations of serum TNF-α/IL-6.

Source: The Journal of Nutritional Biochemistry - February 9, 2017 Category: Biochemistry Authors: Kaiping Wang, Zhuohong Tang, Jinglin Wang, Peng Cao, Qiang Li, Weizhi Shui, Hongjing Wang, Ziming Zheng, Yu Zhang Source Type: research