A food-based approach that targets IL-6, a key regulator of chronic intestinal inflammation and colon carcinogenesis

Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic cell proliferation and chronic inflammation in a HCD-consuming human-relevant pig model. We observed elevated colonic mucosal IL-6 expression in HCD-consuming pigs compared to standard diet controls (SD, P=.04) and IL-6 strongly correlated with Ki-67 proliferative index and zone, early biomarkers of colon cancer risk (r=0.604, 0.743; P=.017, 0.002; respectively).

Source: The Journal of Nutritional Biochemistry - January 27, 2017 Category: Biochemistry Authors: Abigail Sido, Sridhar Radhakrishnan, Sung Woo Kim, Elisabeth Eriksson, Frank Shen, Qunhua Li, Vadiraja Bhat, Lavanya Reddivari, Jairam K.P. Vanamala Source Type: research