The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Maternal low-protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring
Prenatal exposure to a maternal low-protein (LP) diet has been known to cause cognitive impairment, learning and memory deficits. However, the underlying mechanisms have not been identified. Herein, we demonstrate that a maternal LP diet causes, in the brains of the neonatal rat offspring, an attenuation in the basal expression of the brain-derived neurotrophic factor (BDNF), a neurotrophin indispensable for learning and memory. Female rats were fed either a 20% normal protein (NP) diet or an 8% LP 3 weeks before breeding and during the gestation period. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 6, 2017 Category: Biochemistry Authors: Gurdeep Marwarha, Kate Claycombe-Larson, Jared Schommer, Othman Ghribi Tags: Research article Source Type: research

UHPLC-Q-Orbitrap-HRMS-based global metabolomics reveal metabolome modifications in plasma of young women after cranberry juice consumption
Plasma metabolome in young women following cranberry juice consumption were investigated using a global UHPLC-Q-Orbitrap-HRMS approach. Seventeen female college students, between 21 –29 years old, were given either cranberry juice or apple juice for three days using a cross-over design. Plasma samples were collected before and after juice consumption. Plasma metabolomes were analyzed using UHPLC-Q-Orbitrap-HRMS followed by orthogonal partial least squares-discriminant analyse s (OPLS-DA). S-plot was used to identify discriminant metabolites. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 6, 2017 Category: Biochemistry Authors: Haiyan Liu, Timothy J. Garrett, Zhihua Su, Christina Khoo, Liwei Gu Source Type: research

Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by metabolic disturbances in specific tissues. The present work aimed to analyse the effects of xanthohumol (XN) and 8-prenylnaringenin (8PN), two beer-derived polyphenols, in liver and skeletal muscle lipid and glycolytic metabolism in T2DM mice model. Thirty C57Bl/6 mice were randomly divided into 5 groups: standard diet (control), high-fat diet, DM), high-fat diet plus ethanol (DM-Ethanol), high-fat diet plus 10 mg/L XN (DM-XN), and high-fat diet plus 10 mg/L 8PN (DM-8PN) during 20 weeks. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 6, 2017 Category: Biochemistry Authors: Raquel Costa, Ilda Rodrigues, Lu ísa Guardão, Sílvia Rocha-Rodrigues, Carolina Silva, José Magalhães, Manuel Ferreira-de-Almeida, Rita Negrão, Raquel Soares Source Type: research

Maternal low protein diet decreases brain-derived neurotrophic factor expression in the brains of the neonatal rat offspring
Prenatal exposure to a maternal low protein diet has been known to cause cognitive impairment, learning and memory deficits. However, the underlying mechanisms have not been identified. Herein, we demonstrate that a maternal low protein (LP) diet causes, in the brains of the neonatal rat offspring, an attenuation in the basal expression of the brain-derived neurotrophic factor (BDNF), a neurotrophin indispensable for learning and memory. Female rats were fed either a 20% normal protein diet (NP) or an 8% low protein (LP) three weeks before breeding and during the gestation period. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 6, 2017 Category: Biochemistry Authors: Gurdeep Marwarha, Kate Claycombe-Larson, Jared Schommer, Othman Ghribi Source Type: research

Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice
The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging and cellular damage. Quality control systems, such as the unfolded protein response (UPR), inflammatory signaling and protein degradation, mitigate the residence time of damaged proteins. In the present study, we have examined the UPR and inflammatory signaling in the liver of young (~6 mo.) and old (~28 mo.) mice (n=8/group), and the ability of trehalose, a compound linked to increased protein stability and autophagy, to counteract age-induced effects on these systems. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 6, 2017 Category: Biochemistry Authors: Michael J. Pagliassotti, Andrea L. Estrada, William M. Hudson, Yuren Wei, Dong Wang, Douglas R. Seals, Melanie L. Zigler, Thomas J. LaRocca Source Type: research

Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: A key role for triglyceride metabolism
Atherosclerosis-related research has focused mainly on the effects of lipids on macrophage foam cell formation and atherogenesis, whereas the role of amino acids (AA) was understudied. The current study aimed to identify anti- or pro-atherogenic AA in the macrophage model system and to elucidate the underlying metabolic and molecular mechanisms. J774A.1 cultured macrophages were treated with increasing concentrations of each one of the twenty AA. Macrophage atherogenicity was assessed in terms of cellular toxicity, generation of reactive oxygen species (ROS), and cellular cholesterol or triglyceride content. (Source: The J...
Source: The Journal of Nutritional Biochemistry - April 6, 2017 Category: Biochemistry Authors: Oren Rom, Claudia Grajeda-Iglesias, Mahmoud Najjar, Niroz Abu-Saleh, Nina Volkova, Dalit Esther Dar, Tony Hayek, Michael Aviram Source Type: research

Fructose increases corticosterone production in association with NADPH metabolism alterations in rat epididymal white adipose tissue
Metabolic syndrome is an array of closely metabolic disorders that includes glucose intolerance/insulin resistance, central obesity, dyslipidemia, and hypertension. Fructose, a highly lipogenic sugar, has profound metabolic effects in adipose tissue, and has been associated with the etiopathology of many components of the metabolic syndrome. In adipocytes, the enzyme 11 β-HSD1 amplifies local glucocorticoid production, being a key player in the pathogenesis of central obesity and metabolic syndrome. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 5, 2017 Category: Biochemistry Authors: Paula D. Prince, Yanina Santander, Estefania M. Gerez, Christian H öcht, Ariel H. Polizio, Marcos A. Mayer, Carlos A. Taira, Cesar G. Fraga, Monica Galleano, Andrea Carranza Source Type: research

miR-19 Targeting of GSK3 β Mediates Sulforaphane Suppression of Lung Cancer Stem Cells
Cancer stem cells (CSCs) play central role in the development of cancer. The canonical Wnt/ β-catenin pathway is critical for maintaining stemness of CSCs. Phytochemicals from dietary compounds possess anti-CSCs properties and have been characterized as promising therapeutic agents for the prevention and treatment of many cancers. To date, the involvement and function of miR-19, a key onc ogenic miRNA, in regulating Wnt/β-catenin pathway and lung CSCs has not been defined. Meanwhile, the effect of sulforaphane (SFN) on lung CSCs also remains to be elucidated. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 5, 2017 Category: Biochemistry Authors: Jianyun Zhu, Shijia Wang, Yue Chen, Xiaoting Li, Ye Jiang, Xue Yang, Yuan Li, Xiaoqian Wang, Yu Meng, Mingming Zhu, Xiao Ma, Cong Huang, Rui Wu, Chunfeng Xie, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Hongyu Han Source Type: research

Early-in-life dietary zinc deficiency and supplementation and mammary tumor development in adulthood female rats
Zinc deficiency during pregnancy and postnatal life can adversely increase risk of developing human diseases at adulthood. The present study was designed to evaluate whether dietary zinc deficiency or supplementation during the pregnancy, lactation and juvenile stages interferes in the development of mammary tumors induced by 7,12-dimethylbenzanthracene (DMBA) in female Sprague –Dawley (SD) rats. Pregnant female SD rats were allocated into three groups: zinc-adequate diet (ZnA - 35-mg/kg chow), zinc-deficient diet (ZnD - 3-mg/kg chow) or zinc-supplemented diet (ZnS - 180-mg/kg chow) during gestational day 10 (GD 10) unti...
Source: The Journal of Nutritional Biochemistry - April 1, 2017 Category: Biochemistry Authors: Fl ávia R.M. da Silva, Tony F. Grassi, Joyce R. Zapaterini, Lucas T. Bidinotto, Luis F. Barbisan Tags: Research Article Source Type: research

Early in life dietary zinc deficiency and supplementation and mammary tumors development in adulthood female rats
Zinc deficiency during pregnancy and postnatal life can adversely increase risk of developing human diseases at adulthood. The present study was designed to evaluate whether dietary zinc deficiency or supplementation during the pregnancy, lactation and juvenile stages interferes in the development of mammary tumors induced by 7,12-dimethylbenzanthracene (DMBA) in female Sprague –Dawley (SD) rats. Pregnant female SD rats were allocated into three groups: zinc adequate diet (ZnA - 35 mg/Kg chow), zinc deficient diet (ZnD - 3 mg/Kg chow), or zinc supplemented diet (ZnS - 180 mg/Kg chow) during gestational day 10 (GD 10) unt...
Source: The Journal of Nutritional Biochemistry - April 1, 2017 Category: Biochemistry Authors: Fl ávia R.M. da Silva, Tony F. Grassi, Joyce R. Zapaterini, Lucas T. Bidinotto, Luis F. Barbisan Source Type: research

Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities
Polyphenols from persimmon (Diospyros kaki) have demonstrated radical-scavenging and anti-inflammatory activities, however little is known about the effects of persimmon phenolics on inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Therefore, we aimed in this work, to characterize the anti-inflammatory and anti-proliferative effects of a persimmon phenolic extract (80% acetone in water), using an in vivo model of experimental colitis and a model of cancer cell invasion. Our results show, for the first time, a beneficial effect of a persimmon phenolic extract in the attenuation of experimental colitis and a po...
Source: The Journal of Nutritional Biochemistry - March 29, 2017 Category: Biochemistry Authors: Rosa Direito, Ana Lima, Jo ão Rocha, Ricardo Boavida Ferreira, Joana Mota, Patrícia Rebelo, Adelaide Fernandes, Rui Pinto, Paula Alves, Rosário Bronze, Bruno Sepodes, Maria-Eduardo Figueira Source Type: research

Ferulic acid-4-O-sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice
Consumption of foods rich in ferulic acid (FA) such as wholegrain cereals, or FA precursors such as chlorogenic acids in coffee, is inversely correlated with risk of cardiovascular disease and type 2 diabetes. As a result of digestion and phase II metabolism in the gut and liver, FA is converted predominantly into ferulic acid-4-O-sulfate (FA-sul), an abundant plasma metabolite. Although FA-sul may be the main metabolite, very little has been reported regarding its bioactivities. We have therefore compared the ex vivo vasorelaxing effect of FA and FA-sul (10 −7 - 3.10−5M) on isolated mouse arteries mounted in tissue my...
Source: The Journal of Nutritional Biochemistry - March 23, 2017 Category: Biochemistry Authors: Evelien Van Rymenant, John Van Camp, Bart Pauwels, Charlotte Boydens, Laura Vanden Daele, Katrijn Beerens, Peter Brouckaert, Guy Smagghe, Asimina Kerimi, Gary Williamson, Charlotte Grootaert, Johan Van de Voorde Source Type: research

Dietary rose hip exerts antiatherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice
Atherosclerosis is a disease in which atheromatous plaques develop inside arteries, leading to reduced or obstructed blood flow that in turn may cause stroke and heart attack. Rose hip is the fruit of plants of the genus Rosa, belonging to the Rosaceae family, and it is rich in antioxidants with high amounts of ascorbic acid and phenolic compounds. Several studies have shown that fruits, seeds and roots of these plants exert antidiabetic, antiobesity and cholesterol-lowering effects in rodents as well as humans. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 20, 2017 Category: Biochemistry Authors: Michele Cavalera, Ulrika Axling, Catarina Rippe, Karl Sw ärd, Cecilia Holm Tags: Research Article Source Type: research

Dietary rose hip exerts anti-atherosclerotic effects and increases nitric oxide-mediated dilation in ApoE-null mice
Atherosclerosis is a disease in which atheromatous plaques develop inside arteries, leading to reduced or obstructed blood flow that in turn may cause stroke and heart attack. Rose hip is the fruit of plants of the genus Rosa, belonging to the Rosaceae family, and it is rich in antioxidants with high amounts of ascorbic acid and phenolic compounds. Several studies have shown that fruits, seeds and roots of these plants exert anti-diabetic, anti-obesity and cholesterol-lowering effects in rodents as well as humans. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 19, 2017 Category: Biochemistry Authors: Michele Cavalera, Ulrika Axling, Catarina Rippe, Karl Sw ärd, Cecilia Holm Source Type: research

Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells
Although curcumin shows anti-proliferative and anti-inflammatory activities in various cancers, the effect of curcumin on cellular migration in endometrial adenocarcinoma cells remains to be understood. The current investigation was aimed to explore the anti-proliferative and anti-migratory effects of curcumin and its mechanism of action in endometrial cancer cells. Our in-vitro and in-vivo experimental studies showed that curcumin inhibited the proliferation of endometrial cancer cells and suppressed the tumor growth in Ishikawa xenograft mouse model. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 18, 2017 Category: Biochemistry Authors: Vijay Kumar Sirohi, Pooja Popli, Pushplata Sankhwar, Jyoti Bala Kaushal, Kanchan Gupta, Murli Manohar, Anila Dwivedi Tags: Research Article Source Type: research