Fructose increases corticosterone production in association with NADPH metabolism alterations in rat epididymal white adipose tissue

Metabolic syndrome is an array of closely metabolic disorders that includes glucose intolerance/insulin resistance, central obesity, dyslipidemia, and hypertension. Fructose, a highly lipogenic sugar, has profound metabolic effects in adipose tissue, and has been associated with the etiopathology of many components of the metabolic syndrome. In adipocytes, the enzyme 11 β-HSD1 amplifies local glucocorticoid production, being a key player in the pathogenesis of central obesity and metabolic syndrome.

Source: The Journal of Nutritional Biochemistry - April 5, 2017 Category: Biochemistry Authors: Paula D. Prince, Yanina Santander, Estefania M. Gerez, Christian H öcht, Ariel H. Polizio, Marcos A. Mayer, Carlos A. Taira, Cesar G. Fraga, Monica Galleano, Andrea Carranza Source Type: research