Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: A key role for triglyceride metabolism

Atherosclerosis-related research has focused mainly on the effects of lipids on macrophage foam cell formation and atherogenesis, whereas the role of amino acids (AA) was understudied. The current study aimed to identify anti- or pro-atherogenic AA in the macrophage model system and to elucidate the underlying metabolic and molecular mechanisms. J774A.1 cultured macrophages were treated with increasing concentrations of each one of the twenty AA. Macrophage atherogenicity was assessed in terms of cellular toxicity, generation of reactive oxygen species (ROS), and cellular cholesterol or triglyceride content.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research