Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities

Polyphenols from persimmon (Diospyros kaki) have demonstrated radical-scavenging and anti-inflammatory activities, however little is known about the effects of persimmon phenolics on inflammatory bowel diseases (IBD) and colorectal cancer (CRC). Therefore, we aimed in this work, to characterize the anti-inflammatory and anti-proliferative effects of a persimmon phenolic extract (80% acetone in water), using an in vivo model of experimental colitis and a model of cancer cell invasion. Our results show, for the first time, a beneficial effect of a persimmon phenolic extract in the attenuation of experimental colitis and a potential antiproliferative effect on cultured colon cancer cells.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research