The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Whole flaxseed diet alters estrogen metabolism to promote 2-methoxtestradiol-induced apoptosis in hen ovarian cancer
In this study, we analyzed the effects of the two main components of whole flaxseed, ligan and omega 3 fatty acids, on estrogen metabolism and the estrogen receptor in ovarian tumors. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 22, 2017 Category: Biochemistry Authors: Anushka Dikshit, Karen Hales, Dale Buchanan Hales Source Type: research

All-trans-retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting NF- κB signaling
An effect of the vitamin A metabolite all-trans-retinoic acid (ATRA) on body weight regulation and adiposity has been described, but little is known about its impact on obesity-associated inflammation. Our objective was to evaluate the overall impact of this metabolite on inflammatory response in human and mouse adipocytes, using high-throughput methods, and to confirm its effects in a mouse model. ATRA (2 μM for 24 h) downregulated the mRNA expression of 17 chemokines in human adipocytes, and limited macrophage migration in a TNFα-conditioned 3 T3-L1 adipocyte medium (73.7%, P (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 22, 2017 Category: Biochemistry Authors: Esma Karkeni, Lauriane Bonnet, Julien Astier, Charl ène Couturier, Julie Dalifard, Franck Tourniaire, Jean-François Landrier Source Type: research

Effect of a cocoa diet on the small intestine and gut-associated lymphoid tissue composition in an oral sensitization model in rats
Previous studies have attributed to the cocoa powder the capacity to attenuate the immune response in a rat oral sensitization model. To gain a better understanding of cocoa-induced mechanisms at small intestinal level, three-week-old female Lewis rats were fed either a standard diet or a diet containing 10% cocoa for four weeks with or without concomitant oral sensitization with ovalbumin (OVA). Thereafter, we evaluated the lymphocyte composition of the Peyer's patches (PPL), small intestine epithelium (IEL) and lamina propria (LPL). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 22, 2017 Category: Biochemistry Authors: Mariona Camps-Bossacoma, Francisco J. P érez-Cano, Àngels Franch, Eva Untersmayr, Margarida Castell Source Type: research

Obesity Alters the Ovarian Glucidic Homeostasis Disrupting the Reproductive Outcome of Female Rats
Obesity constitutes a health problem of increasing worldwide prevalence related to many reproductive problems such as infertility, ovulation dysfunction, preterm delivery, fetal growth disorders, etc. The mechanisms linking obesity to these pathologies are not fully understood. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects western diet habits. Previously we described that CAF induces obesity associated to hyperglycemia, reduced ovarian reserve, presence of follicular cysts and ovulatory impairments. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 19, 2017 Category: Biochemistry Authors: MV Bazzano, DA Paz, EM Elia Source Type: research

Maternal consumption of low-isoflavone soy protein isolate alters hepatic gene expression and liver development in rat offspring
In utero environment is known to affect fetal development. Especially, the distinct fetal programming of carcinogenesis was reported in offspring exposed to maternal diets containing soy protein isolate (SPI) or genistein. Therefore, we investigated whether maternal consumption of a low-isoflavone SPI or genistein alters hepatic gene expression and liver development in rat offspring. Female Sprague –Dawley rats were fed a casein diet, a low-isoflavone SPI diet, or a casein diet supplemented with genistein (250 mg/kg diet) for two weeks before mating and throughout pregnancy and lactation. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 13, 2017 Category: Biochemistry Authors: Sae Bom Won, Anna Han, Young Hye Kwon Source Type: research

17 β-Estradiol Enhances Sulforaphane Cardioprotection Against Oxidative Stress
The lower incidence of ischemic heart disease in female respect male gender suggests the possibility that female sex hormones could have specific effects in cardiovascular protection. 17 β-estradiol is the predominant pre-menopausal circulating form of estrogen and has a protective role on the cardiovascular system. Recent evidences suggest that gender can influence the response to cardiovascular medications, therefore we hypothesized that sex hormones could also modulate the cardi oprotective effects of nutraceutical compounds, such as the isothiocyanate sulforaphane, present in Brassica vegetables. (Source: The Journal ...
Source: The Journal of Nutritional Biochemistry - January 13, 2017 Category: Biochemistry Authors: Cristina Angeloni, Gabriella Teti, Maria Cristina Barbalace, Marco Malaguti, Mirella Falconi, Silvana Hrelia Source Type: research

Quercetin, a functional compound of onion peel, remodels white adipocytes to brown-like adipocytes
Adipocyte browning is a promising strategy for obesity prevention. Using onion peel-derived extracts and their bioactive compounds, we demonstrate that the onion peel, a by-product of the onion, can change the characteristics of white adipocytes to those of brown-like adipocytes in the white adipose tissue of mice and in 3 T3-L1 cells. The expression of the following brown adipose tissue-specific genes was increased in the retroperitoneal and subcutaneous adipose tissues of 0.5% onion peel extract-fed mice: PR domain-containing 16, peroxisome proliferator-activated receptor gamma coactivator 1 α, uncoupling protein 1, fib...
Source: The Journal of Nutritional Biochemistry - January 13, 2017 Category: Biochemistry Authors: Sang Gil Lee, John S. Parks, Hye Won Kang Source Type: research

Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice
Ulcerative colitis is the typical progression of chronic inflammatory bowel disease. Amino acids, particularly tryptophan, have been reported to exert a protective effect against colitis induced by dextran sodium sulfate (DSS), but the precise underlying mechanisms remain incompletely clarified. Tryptophan metabolites are recognized to function as endogenous ligands for aryl hydrocarbon receptor (Ahr), which is a critical regulator of inflammation and immunity. Thus, we conducted this study to investigate whether dietary tryptophan supplementation protects against DSS-induced colitis by acting through Ahr. (Source: The Jou...
Source: The Journal of Nutritional Biochemistry - January 13, 2017 Category: Biochemistry Authors: Jahidul Islam, Shoko Sato, Kouichi Watanabe, Takaya Watanabe, Ardiansyah, Keisuke Hirahara, Yukihide Aoyama, Shuhei Tomita, Hisashi Aso, Michio Komai, Hitoshi Shirakawa Source Type: research

Long non-coding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer
Long non-coding RNAs (lncRNAs) have emerged as important in cancer development and progression. The impact of diet on lncRNA expression is largely unknown. Sulforaphane (SFN), obtained from vegetables like broccoli, can prevent and suppress cancer formation. Here we tested the hypothesis that SFN attenuates the expression of cancer-associated lncRNAs. We analyzed whole genome RNA-sequencing data of normal human prostate epithelial cells and prostate cancer cells treated with 15 μM SFN or DMSO. SFN significantly altered expression of~100 lncRNAs in each cell type, and normalized the expression of some lncRNAs that were dif...
Source: The Journal of Nutritional Biochemistry - January 12, 2017 Category: Biochemistry Authors: Laura M. Beaver, Rachael Kuintzle, Alex Buchanan, Michelle W. Wiley, Sarah T. Glasser, Carmen P. Wong, Gavin S. Johnson, Jeff H. Chang, Christiane V. L öhr, David E. Williams, Roderick H. Dashwood, David A. Hendrix, Emily Ho Source Type: research

Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by downregulating iNOS, inducing anti-oxidative enzymes and arresting cell cycle progression
In this study, to better understand the role of colonic metabolites of NOB, we determined the anti-inflammation and anti-cancer effects of a mixture of NOB and its major metabolites (NOB-Met) at the concentrations equivalent to those found in colonic tissues of NOB-fed mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 9, 2017 Category: Biochemistry Authors: Xian Wu, Mingyue Song, Zili Gao, Yue Sun, Minqi Wang, Fang Li, Jinkai Zheng, Hang Xiao Source Type: research

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells
Plant-derived polyphenols are known to possess anti-inflammatory and anti-oxidant effects. In recent years, several studies have investigated their potential benefits for treating chronic diseases associated with prolonged inflammation and excessive oxidative stress, such as age-related macular degeneration (AMD). Previously, two polyphenols, fisetin and luteolin, have been reported to increase the survival of retinal pigment epithelial (RPE) cells suffering from oxidative stress as well as decreasing inflammation but the benefits of polyphenol therapy seem to depend on the model system used. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 8, 2017 Category: Biochemistry Authors: M Hytti, D Szab ó, N Piippo, E Korhonen, P Honkakoski, K Kaarniranta, G Petrovski, A Kauppinen Source Type: research

Omija fruit ethanol extract improves adiposity and related metabolic disturbances in mice fed a high-fat diet
This study investigated the biological and molecular mechanisms underlying the anti-obesity effect of omija fruit ethanol extract (OFE) in mice fed a high-fat diet (HFD). C57BL/6 J mice were fed a HFD (20% fat, w/w) with or without OFE (500 mg/ kg body weight) for 16 weeks. Dietary OFE significantly increased brown adipose tissue weight and energy expenditure while concomitantly decreasing white adipose tissue (WAT) weight and adipocyte size by up-regulating the expression of brown fat-selective genes in WAT. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 8, 2017 Category: Biochemistry Authors: Hyo Jin Park, Hye-Jin Kim, Sang Ryong Kim, Myung-Sook Choi, Un Ju Jung Source Type: research

Down-regulation of histone deacetylase 4, −5, and−6 as a mechanism of synergistic enhancement of apoptosis in human lung cancer cells treated with the combination of a synthetic retinoid, Am80, and green tea catechin
( −)-Epigallocatechin gallate (EGCG), a green tea catechin, acts as a synergist with various anti-cancer drugs, including retinoids. Am80 is a synthetic retinoid with a different structure from all-trans-retinoic acid: Am80 is now clinically utilized as a new drug for relapsed and intractable acute promyelocytic leukemia patients. Our experiments showed that the combination of EGCG and Am80 synergistically induced both apoptosis in human lung cancer cell line PC-9 and up-regulated expressions of growth arrest and DNA damage-inducible gene 153 (GADD153), death receptor 5, and p21waf1 genes in t he cells. (Source: The Jour...
Source: The Journal of Nutritional Biochemistry - January 7, 2017 Category: Biochemistry Authors: Yukiko Oya, Anupom Mondal, Anchalee Rawangkan, Sonthaya Umsumarng, Keisuke Iida, Tatsuro Watanabe, Miki Kanno, Kaori Suzuki, Zhenghao Li, Hiroyuki Kagechika, Koichi Shudo, Hirota Fujiki, Masami Suganuma Source Type: research

Supra-nutritional selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS/PI3K/AKT signaling and decreased PGC-1 α expression in male Sprague–Dawley rats
Selenium (Se)-enriched milk provides anti-oxidant benefits and has therapeutic potential against cancer. However, both anti-diabetic and pro-diabetic effects have been attributed to Se. Our objective was to evaluate the effect of Se-enriched milk casein on insulin sensitivity in rats when given at the requirement of 0.25 ppm Se and supra-nutritionally on both low- and high-fat diets. 216 male Sprague –Dawley rats were fed low- or high-fat diets containing 1, 2 or 8 times the Se requirement in a randomized block design. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 5, 2017 Category: Biochemistry Authors: Priska Stahel, Julie J. Kim, Scott R.L. Cieslar, Jenny M. Warrington, Changting Xiao, John P. Cant Source Type: research

Quercetin induces apoptosis and autophagy in Primary Effusion Lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways
In this study, we found that quercetin inhibited PI3K/AKT/mTOR and ST AT3 pathways in PEL cells and, as a consequence, it down-regulated the expression of the pro-survival cellular proteins such as c-FLIP, cyclin D1 and cMyc. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - January 3, 2017 Category: Biochemistry Authors: Marisa Granato, Celeste Rizzello, Maria Saveria Gilardini Montani, Laura Cuomo, Marina Vitillo, Roberta Santarelli, Roberta Gonnella, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone Source Type: research