Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells

Plant-derived polyphenols are known to possess anti-inflammatory and anti-oxidant effects. In recent years, several studies have investigated their potential benefits for treating chronic diseases associated with prolonged inflammation and excessive oxidative stress, such as age-related macular degeneration (AMD). Previously, two polyphenols, fisetin and luteolin, have been reported to increase the survival of retinal pigment epithelial (RPE) cells suffering from oxidative stress as well as decreasing inflammation but the benefits of polyphenol therapy seem to depend on the model system used.

Source: The Journal of Nutritional Biochemistry - January 8, 2017 Category: Biochemistry Authors: M Hytti, D Szab ó, N Piippo, E Korhonen, P Honkakoski, K Kaarniranta, G Petrovski, A Kauppinen Source Type: research