All-trans-retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting NF- κB signaling

An effect of the vitamin A metabolite all-trans-retinoic acid (ATRA) on body weight regulation and adiposity has been described, but little is known about its impact on obesity-associated inflammation. Our objective was to evaluate the overall impact of this metabolite on inflammatory response in human and mouse adipocytes, using high-throughput methods, and to confirm its effects in a mouse model. ATRA (2 μM for 24 h) downregulated the mRNA expression of 17 chemokines in human adipocytes, and limited macrophage migration in a TNFα-conditioned 3 T3-L1 adipocyte medium (73.7%, P
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research