Maternal consumption of low-isoflavone soy protein isolate alters hepatic gene expression and liver development in rat offspring

In utero environment is known to affect fetal development. Especially, the distinct fetal programming of carcinogenesis was reported in offspring exposed to maternal diets containing soy protein isolate (SPI) or genistein. Therefore, we investigated whether maternal consumption of a low-isoflavone SPI or genistein alters hepatic gene expression and liver development in rat offspring. Female Sprague –Dawley rats were fed a casein diet, a low-isoflavone SPI diet, or a casein diet supplemented with genistein (250 mg/kg diet) for two weeks before mating and throughout pregnancy and lactation.

Source: The Journal of Nutritional Biochemistry - January 13, 2017 Category: Biochemistry Authors: Sae Bom Won, Anna Han, Young Hye Kwon Source Type: research