The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells
Although curcumin shows anti-proliferative and anti-inflammatory activities in various cancers, the effect of curcumin on cellular migration in endometrial adenocarcinoma cells remains to be understood. The current investigation was aimed to explore the anti-proliferative and anti-migratory effects of curcumin and its mechanism of action in endometrial cancer cells. Studies in in-vitro and in-vivo experimental models of endometrial cancer showed that curcumin inhibited the proliferation of endometrial cancer cells and suppressed the tumor growth in Ishikawa xenograft mouse model. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 17, 2017 Category: Biochemistry Authors: Vijay Kumar Sirohi, Pooja Popli, Pushplata Sankhwar, Jyoti Bala Kaushal, Kanchan Gupta, Murli Manohar, Anila Dwivedi Source Type: research

Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats
In this study, we evaluated the effect of pterostilbene on the pathogenesis of obesity and energy metabolism in obese rats.Pterostilbene significantly activates silent mating type information regulation 2 homolog-1 and peroxisome proliferator-activated receptor-alpha in vitro. Four weeks a 0.5% pterostilbene diet markedly suppressed the abdominal white adipose tissue (WAT) accumulation in obese rats. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 6, 2017 Category: Biochemistry Authors: Koji Nagao, Tomoyuki Jinnouchi, Shunichi Kai, Teruyoshi Yanagita Source Type: research

Guava fruit extract and its triterpene constituents have osteoanabolic effect: stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/ β-catenin signalling
The aim of this study was to evaluate the skeletal effect of guava polyphenol-enriched extract (GE) in rats and identify osteogenic compounds thereof, and determine their modes of action. In growing female rats, GE at 250 mg/kg dose increased parameters of peak bone mass including femur length, bone mineral density (BMD) and biomechanical strength, suggesting that GE promoted modelling-directed bone growth. GE also stimulated bone regeneration at the site of bone injury. In adult osteopenic rats (osteopenia induced by ovariectomy, OVX) GE completely restored the lost bones at both axial and appendicular sites, suggesting a...
Source: The Journal of Nutritional Biochemistry - March 6, 2017 Category: Biochemistry Authors: Konica Porwal, Subhashis Pal, Kapil Dev, Shyamsundar Pal China, Yogesh Kumar, Chandan Singh, Tarun Barbhuyan, Neeraj Sinha, Sabyasachi Sanyal, Arun Kumar Trivedi, Rakesh Maurya, Naibedya Chattopadhyay Source Type: research

Dietary Fructose Augments Ethanol-Induced Liver Pathology
Certain dietary components, when combined with alcohol exacerbate alcohol-induced liver injury (ALI). Here, we tested whether fructose, a major ingredient of the western diet, enhances the severity of ALI. We fed mice ethanol for eight wk. in the following Lieber-DeCarli diets: (1) Regular (contains olive oil), (2) Corn oil (contains corn oil), (3) Fructose (contains fructose and olive oil) and (4) Corn+Fructose (contains fructose and corn oil). We compared indices of metabolic function and liver pathology among the different groups. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 4, 2017 Category: Biochemistry Authors: Paul G. Thomes, Jennifer H. Benbow, Elizabeth Brandon-Warner, Kyle J. Thompson, Carl Jacobs, Terrence M. Donohue, Laura W. Schrum Source Type: research

Role of Pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade
In this study, we investigated PTS confer protection against cytokine stress in MIN6, a pancreatic beta cells, and its role in insulin secretion in streptozotocin (STZ)-induced diabetic mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 4, 2017 Category: Biochemistry Authors: Dornadula Sireesh, MR Ganesh, Umapathy Dhamodharan, Vadivel Sakthi, Sivasubramanian Srinivasan, Gunasekaran Palani, Kunka Mohanram Ramkumar Source Type: research

Caloric dose-responsive genes in blood cells differentiate the metabolic status of obese men
We have investigated the postprandial transcriptional response of blood cells to increasing caloric doses of a meal challenge to test whether the dynamic response of the human organism to the ingestion of food is dependent on metabolic health.The randomized crossover study included seven normal weight and seven obese men consuming three doses (500/1000/1500 kcal) of a high-fat meal. The blood cell transcriptome was measured before and 2, 4, and 6 h after meal ingestion (168 samples). We applied univariate and multivariate statistics to investigate differentially expressed genes in both study groups. (Source: The Journal of...
Source: The Journal of Nutritional Biochemistry - March 4, 2017 Category: Biochemistry Authors: Doreen Gille, Nadine Zangger, Charlotte Soneson, Ueli B ütikofer, Mauro Delorenzi, Flurina Schwander, Katrin A. Kopf-Bolanz, Magali Chollet, Barbara Walther, Kurt Laederach, Guy Vergères Tags: Research Article Source Type: research

Caloric-dose responsive genes in blood cells differentiate the metabolic status of obese men
We have investigated the postprandial transcriptional response of blood cells to increasing caloric doses of a meal challenge to test whether the dynamic response of the human organism to the ingestion of food is dependent on metabolic health.The randomized crossover study included seven normal weight and seven obese men consuming three doses (500/1000/1500 kcal) of a high-fat meal. The blood cell transcriptome was measured before and 2, 4, and 6 h after meal ingestion (168 samples). We applied univariate and multivariate statistics to investigate differentially expressed genes in both study groups. (Source: The Journal of...
Source: The Journal of Nutritional Biochemistry - March 3, 2017 Category: Biochemistry Authors: Doreen Gille, Nadine Zangger, Charlotte Soneson, Ueli B ütikofer, Mauro Delorenzi, Flurina Schwander, Katrin A. Kopf-Bolanz, Magali Chollet, Barbara Walther, Kurt Laederach, Guy Vergères Source Type: research

Kefir alleviates obesity and hepatic steatosis in high-fat diet-fed mice by modulation of gut microbiota and mycobiota: Targeted and untargeted community analysis with correlation of biomarkers
In this study, the anti-obesity and anti-non-alcoholic fatty liver disease (NAFLD) effects of kefir were comprehensively addressed along with targeted and untargeted community analysis of the fecal microbiota in a high-fat diet (HFD)-induced obese mouse model. HFD-fed C57BL/6 mice were orally administrated either kefir or milk (control) once a day for 12 weeks, and body and organ weight, fecal microbiota and mycobiota, histopathology, blood cholesterol and cytokines, and gene expressions were analyzed. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 3, 2017 Category: Biochemistry Authors: Dong-Hyeon Kim, Hyunsook Kim, Dana Jeong, Il-Byeong Kang, Jung-Whan Chon, Hong-Seok Kim, Kwang-Young Song, Kun-Ho Seo Tags: Research article Source Type: research

Grape powder consumption affects the expression of neurodegeneration-related brain proteins in rats chronically fed a high-fructose-high-fat diet
Abnormal glucose metabolism in the brain is recognized to be associated with cognitive decline. Because grapes are rich in polyphenols that produce antioxidative and blood sugar-lowering effects, we investigated how grape consumption affects the expression and/or phosphorylation of neurodegeneration-related brain proteins in aged rats fed a high-fructose-high-fat (HFHF) diet. Wistar rats were maintained on the HFHF diet from the age of 8 weeks to 66 weeks, and then on a HFHF diet containing either 3% or 6% grape powder as an intervention for 12 weeks. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 2, 2017 Category: Biochemistry Authors: Hsiang Liao, Liang-Mao Chou, Yi-Wen Chien, Chi-Hao Wu, Jong-Su Chang, Ching-I Lin, Shyh-Hsiang Lin Source Type: research

The protective role of plant biophenols in mechanisms of Alzheimer's disease
Self-assembly of amyloid beta peptide (A β) into the neurotoxic oligomers followed by fibrillar aggregates are defining characteristics of Alzheimer's disease (AD). Several lines of proposed hypotheses have suggested the mechanism of AD pathology, though the exact pathophysiological mechanism is not yet elucidated. The poor understanding of AD and multitude of adverse responses reported from the current synthetic drugs are the leading cause of failure in the drug development to treat or halt the progression of AD, and mandate the search for safer and more efficient alternatives. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 2, 2017 Category: Biochemistry Authors: Syed H. Omar, Christopher J. Scott, Adam S. Hamlin, Hassan K. Obied Source Type: research

Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis —involvement of the miR-145/p70S6K1/HIF1α axis in vivo and in vitro
This study investigated the potential role of the p70S6K1/HIF1 α axis in the anti-inflammatory activities of pomegranate (Punica granatum L.) polyphenolics in dextran sodium sulfate (DSS)-induced colitis in Sprague–Dawley rats and in lipopolysaccharide (LPS)-treated CCD-18Co colon-myofibroblastic cells. Rats were administered either control (CT) or pomegrana te beverage (PG), containing ellagic acid and ellagitannins, then exposed to three cycles of 3% DSS followed by a 2-week recovery period. PG protected against DSS-induced colon inflammation and ulceration (50% and 66.7%, P=.05 and .045, respectively), and decreased ...
Source: The Journal of Nutritional Biochemistry - February 26, 2017 Category: Biochemistry Authors: Hyemee Kim, Nivedita Banerjee, Maritza A. Sirven, Yasushi Minamoto, Melissa E. Markel, Jan S. Suchodolski, Stephen T. Talcott, Susanne U. Mertens-Talcott Source Type: research

Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis - involvement of the miR-145/p70S6K1/HIF1 α axis in vivo and in vitro
This study investigated the potential role of the p70S6K1/HIF1 α axis in the anti-inflammatory activities of pomegranate (Punica granatum L.) polyphenolics in dextran sodium sulfate (DSS)-induced colitis in Sprague–Dawley rats and in lipopolysaccharide (LPS)-treated CCD-18Co colon-myofibroblastic cells. Rats were administered either control (CT) or pomegrana te beverage (PG), containing ellagic acid and ellagitannins, then exposed to three cycles of 3% DSS followed by a 2-week recovery period. PG protected against DSS-induced colon inflammation and ulceration (50% and 66.7%, P=.05 and 0.045, respectively), and decreased...
Source: The Journal of Nutritional Biochemistry - February 25, 2017 Category: Biochemistry Authors: Hyemee Kim, Nivedita Banerjee, Maritza A Sirven, Yasushi Minamoto, Melissa E. Markel, Jan S. Suchodolski, Stephen T. Talcott, Susanne U. Mertens-Talcott Source Type: research

Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs palm oil-rich diets
Obesity and type 2 diabetes are nutritional pathologies, characterized by a subclinical inflammatory state. Endotoxins are now well recognized as an important factor implicated in the onset and maintain of this inflammatory state during fat digestion in high-fat diet. As a preventive strategy, lipid formulation could be optimized to limit these phenomena, notably regarding fatty acids profile and PL emulsifier content. Little is known about soybean polar lipid (SPL) consumption associated to oils rich in saturated FA vs anti-inflammatory omega-3 FA such as α-linolenic acid on inflammation and metabolic endotoxemia. (Sourc...
Source: The Journal of Nutritional Biochemistry - February 19, 2017 Category: Biochemistry Authors: Manon Lecomte, Leslie Cou ëdelo, Emmanuelle Meugnier, Emmanuelle Loizon, Pascale Plaisancié, Annie Durand, Alain Géloën, Florent Joffre, Carole Vaysse, Marie-Caroline Michalski, Fabienne Laugerette Source Type: research

A lipidomic study on the regulation of inflammation and oxidative stress targeted by Marine ω-3 PUFA and Polyphenols in high- fat high-sucrose diets
AbstractThe ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health are discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 19, 2017 Category: Biochemistry Authors: Gabriel Dasilva, Manuel Pazos, Eduardo Garc ía-Egido, José M. Gallardo, Sara Ramos-Romero, Josep Lluís Torres, Marta Romeu, María-Rosa Nogués, Isabel Medina Source Type: research

Aberrant expression of microRNA induced by high-fructose diet: implications in the pathogenesis of hyperlipidemia and hepatic insulin resistance
Fructose is a highly lipogenic sugar that can alter energy metabolism and trigger metabolic disorders. In the current study, microRNAs (miRNAs) altered by a high-fructose diet were comprehensively explored to elucidate their significance in the pathogenesis of chronic metabolic disorders. miRNA expression profiling using small noncoding RNA sequencing revealed that 19 miRNAs were significantly upregulated and 26 were downregulated in the livers of high-fructose-fed mice compared to chow-fed mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - February 18, 2017 Category: Biochemistry Authors: Neetu Sud, Hanyuan Zhang, Kaichao Pan, Xiao Cheng, Juan Cui, Qiaozhu Su Tags: Research Article Source Type: research