Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells

Although curcumin shows anti-proliferative and anti-inflammatory activities in various cancers, the effect of curcumin on cellular migration in endometrial adenocarcinoma cells remains to be understood. The current investigation was aimed to explore the anti-proliferative and anti-migratory effects of curcumin and its mechanism of action in endometrial cancer cells. Studies in in-vitro and in-vivo experimental models of endometrial cancer showed that curcumin inhibited the proliferation of endometrial cancer cells and suppressed the tumor growth in Ishikawa xenograft mouse model.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research