Pomegranate polyphenolics reduce inflammation and ulceration in intestinal colitis —involvement of the miR-145/p70S6K1/HIF1α axis in vivo and in vitro
This study investigated the potential role of the p70S6K1/HIF1 α axis in the anti-inflammatory activities of pomegranate (Punica granatum L.) polyphenolics in dextran sodium sulfate (DSS)-induced colitis in Sprague–Dawley rats and in lipopolysaccharide (LPS)-treated CCD-18Co colon-myofibroblastic cells. Rats were administered either control (CT) or pomegrana te beverage (PG), containing ellagic acid and ellagitannins, then exposed to three cycles of 3% DSS followed by a 2-week recovery period. PG protected against DSS-induced colon inflammation and ulceration (50% and 66.7%, P=.05 and .045, respectively), and decreased the Ki-67 proliferative index in t he central and basal regions compared to the control.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Hyemee Kim, Nivedita Banerjee, Maritza A. Sirven, Yasushi Minamoto, Melissa E. Markel, Jan S. Suchodolski, Stephen T. Talcott, Susanne U. Mertens-Talcott Source Type: research