The protective role of plant biophenols in mechanisms of Alzheimer's disease

Self-assembly of amyloid beta peptide (A β) into the neurotoxic oligomers followed by fibrillar aggregates are defining characteristics of Alzheimer's disease (AD). Several lines of proposed hypotheses have suggested the mechanism of AD pathology, though the exact pathophysiological mechanism is not yet elucidated. The poor understanding of AD and multitude of adverse responses reported from the current synthetic drugs are the leading cause of failure in the drug development to treat or halt the progression of AD, and mandate the search for safer and more efficient alternatives.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research