Dietary Fructose Augments Ethanol-Induced Liver Pathology

Certain dietary components, when combined with alcohol exacerbate alcohol-induced liver injury (ALI). Here, we tested whether fructose, a major ingredient of the western diet, enhances the severity of ALI. We fed mice ethanol for eight wk. in the following Lieber-DeCarli diets: (1) Regular (contains olive oil), (2) Corn oil (contains corn oil), (3) Fructose (contains fructose and olive oil) and (4) Corn+Fructose (contains fructose and corn oil). We compared indices of metabolic function and liver pathology among the different groups.

Source: The Journal of Nutritional Biochemistry - March 4, 2017 Category: Biochemistry Authors: Paul G. Thomes, Jennifer H. Benbow, Elizabeth Brandon-Warner, Kyle J. Thompson, Carl Jacobs, Terrence M. Donohue, Laura W. Schrum Source Type: research