Caloric-dose responsive genes in blood cells differentiate the metabolic status of obese men

We have investigated the postprandial transcriptional response of blood cells to increasing caloric doses of a meal challenge to test whether the dynamic response of the human organism to the ingestion of food is dependent on metabolic health.The randomized crossover study included seven normal weight and seven obese men consuming three doses (500/1000/1500 kcal) of a high-fat meal. The blood cell transcriptome was measured before and 2, 4, and 6 h after meal ingestion (168 samples). We applied univariate and multivariate statistics to investigate differentially expressed genes in both study groups.

Source: The Journal of Nutritional Biochemistry - March 3, 2017 Category: Biochemistry Authors: Doreen Gille, Nadine Zangger, Charlotte Soneson, Ueli B ütikofer, Mauro Delorenzi, Flurina Schwander, Katrin A. Kopf-Bolanz, Magali Chollet, Barbara Walther, Kurt Laederach, Guy Vergères Source Type: research