The Journal of Nutritional Biochemistry This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dietary dried plum increases bone mass, suppresses pro-inflammatory cytokines and promotes attainment of peak bone mass in male mice
Nutrition is an important determinant of bone health and attainment of peak bone mass. Diets containing dried plum (DP) have been shown to increase bone volume and strength. These effects may be linked to the immune system and DP-specific polyphenols. To better understand these relationships we studied DP in skeletally mature (6-month-old) and growing (1 and 2-month-old) C57Bl/6 male mice. In adult mice, DP rapidly ( (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - May 9, 2016 Category: Biochemistry Authors: Mohammad Shahnazari, Russell T. Turner, Urszula T. Iwaniec, Thomas J. Wronski, Min Li, Mario G. Ferruzzi, Robert A. Nissenson, Bernard P. Halloran Source Type: research

Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis
Compared with the extensor longus digitorum (EDL) muscle of control rats (C), the EDL muscle of rats fed a low-protein, high-carbohydrate (LPHC) diet showed a 36% reduction in mass. Muscle mass is determined by the balance between protein synthesis and proteolysis; thus, the aim of this work was to evaluate the components involved in these processes. Compared with the muscle from C rats, the EDL muscle from LPHC diet-fed rats showed a reduction (34%) in the in vitro basal protein synthesis and a 22% reduction in the in vitro basal proteolysis suggesting that the reduction in the mass can be associated with a change in the ...
Source: The Journal of Nutritional Biochemistry - May 5, 2016 Category: Biochemistry Authors: Maísa Pavani dos Santos, Emanuele Batistela, Mayara Peron Pereira, Silvia Paula Gomes, Neusa Maria Zanon, Isis do Carmo Kettelhut, Christina Karatzaferi, Claudia Marlise Balbinotti Andrade, Suélem Aparecida de França, Amanda Martins Baviera, Nair Honda Source Type: research

Fish oil-derived n-3 polyunsaturated fatty acids reduce NLRP3 inflammasome activity and obesity-related inflammatory cross-talk between adipocytes and CD11b+ macrophages
Adipocyte-macrophage cross-talk propagates immune responses in obese adipose tissue (AT). Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) mitigate inflammation, partly through up-regulation of adiponectin; however, specific mechanisms are unclear. We determined if adipocyte-macrophage cross-talk could be mitigated by dietary LC n-3 PUFA, and if this was dependent on adiponectin-mediated signaling. We utilized an in vitro co-culture model mimicking the ratio of adipocytes:macrophages in obese AT, whereby 3 T3-L1 adipocytes were co-cultured with splenic CD11b+-macrophages from C57BL/6 mice fed high-fat control (HF-C...
Source: The Journal of Nutritional Biochemistry - April 27, 2016 Category: Biochemistry Authors: Anna A. De Boer, Jennifer M. Monk, Danyelle M. Liddle, Amber L. Hutchinson, Krista A. Power, David W.L. Ma, Lindsay E. Robinson Source Type: research

A diet containing grape powder ameliorates the cognitive decline in aged rats with a long-term high-fructose-high-fat dietary pattern
Research has suggested that the consumption of foods rich in polyphenols is beneficial to the cognitive functions of the elderly. We investigated the effects of grape consumption on spatial learning, memory performance, and neurodegeneration-related protein expression in aged rats fed a high-fructose-high-fat (HFHF) diet. Six-week-old Wistar rats were fed an HFHF diet to 66 weeks of age to establish a model of an HFHF dietary pattern, before receiving intervention diets containing different amounts of grape powder for another 12 weeks in the second part of the experiment. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 27, 2016 Category: Biochemistry Authors: Liang-Mao Chou, Ching-I Lin, Yue-Hwa Chen, Hsiang Liao, Shyh-Hsiang Lin Source Type: research

Protective Effects of Maternal Methyl Donor Supplementation on Adult Offspring of High-fat Diet-fed Dams
Obesity has become a global public health problem associated with metabolic dysfunction and chronic disorders. It has been shown that the risk of obesity and the DNA methylation profiles of the offspring can be affected by maternal nutrition, such as HFD consumption. The aim of this study was to investigate whether metabolic dysregulation and physiological abnormalities in offspring caused by maternal HFD can be alleviated by the treatment of methyl donors during pregnancy and lactation of dams. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 27, 2016 Category: Biochemistry Authors: Fei Jiao, Xiaoshuang Yan, Yuan Yu, Xiao Zhu, Ying Ma, Zhen Yue, Hailong Ou, Zhonghai Yan Source Type: research

Resveratrol ameliorates benzo(a)pyrene induced testicular dysfunction and apoptosis: Involvement of p38 MAPK/ATF2/iNOS signalling
Benzo(a)pyrene (B(a)P) is an environmental toxicant that alters the steroidogenic profile of testis and induces testicular dysfunction. In the present study, we have investigated the molecular signalling of B(a)P and the ameliorative potential of the natural Aryl hydrocarbon Receptor (AhR) antagonist and antioxidant, resveratrol on B(a)P induced male reproductive toxicity. Studies showed that B(a)P treatment resulted in p38MAPK activation and increased iNOS production along with testicular apoptosis and steroidogenic dysfunction. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 19, 2016 Category: Biochemistry Authors: Bhaswati Banerjee, Pinki Nandi, Supriya Chakraborty, Sanghamitra Raha, Parimal C. Sen, Kuladip Jana Source Type: research

Autophagy proteins are modulated in the liver and hypothalamus of the offspring of mice with diet-induced obesity
In this study, we tested the hypothesis that maternal obesity induced by a high fat diet (HFD) modulates autophagy proteins in the hypothalamus and liver of the offspring of mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 17, 2016 Category: Biochemistry Authors: Andressa Reginato, Thaís de Fante, Mariana Portovedo, Natália Ferreira da Costa, Tanyara Baliani Payolla, Josiane Érica Miyamotto, Laís Angélica Simino, Letícia M. Ignácio-Souza, Márcio A. Torsoni, Adriana S. Torsoni, Marciane Milanski Source Type: research

Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia
Cardiovascular health is influenced by dietary composition and the western diet is composed of varying types/amounts of fat. Conjugated linoleic acid (cLA) is an abundant dietary unsaturated fatty acid associated with health benefits but its biological signaling is not well understood. Nitrite is enriched in vegetables within the diet and can impact signaling of unsaturated fatty acids, however its role on cLA signaling is not well understood. Elucidating how nitrite may impact the biological signaling of cLA is important due to the dietary consumption of both cLA and nitrite in the western diet. (Source: The Journal of Nu...
Source: The Journal of Nutritional Biochemistry - April 14, 2016 Category: Biochemistry Authors: Patrick M. Van Hoose, Natia Qipshidze Kelm, Kellianne M. Piell, Marsha P. Cole Source Type: research

The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy
The purpose of the present study was to evaluate if interdisciplinary therapy can influence the cardiometabolic and serum free fatty acid profile. The second aim was to evaluate if there are association between serum free fatty acids, inflammation and cardiometabolic biomarkers in obese adolescents with and without metabolic syndrome submitted to a long-term interdisciplinary therapy. The study involved 108 post-puberty obese adolescents, who were divided according to metabolic syndrome (MetS) diagnosis: MetS (n=32) and non-MetS (n=76). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 5, 2016 Category: Biochemistry Authors: Deborah Cristina Landi Masquio, Aline de Piano-Ganen, Lila Missae Oyama, Raquel Munhoz da Silveira Campos, Aline Boveto Santamarina, Gabriel Inácio de Morais Honorato de Souza, Aline Dal’Olio Gomes, Renata Guimarães Moreira, Flávia Campos Corgosinho, Source Type: research

Maternal folic acid supplementation modulates DNA methylation and gene expression in the rat offspring in a gestation period-dependent and organ-specific manner
Maternal folic acid supplementation can alter DNA methylation and gene expression in the developing fetus, which may confer disease susceptibility later in life. We determined which gestation period and organ were most sensitive to the modifying effect of folic acid supplementation during pregnancy on DNA methylation and gene expression in the offspring. Pregnant rats were randomized to a control diet throughout pregnancy; folic acid supplementation at 2.5x the control during the 1st, 2nd, or 3rd week of gestation only; or folic acid supplementation throughout pregnancy. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - April 5, 2016 Category: Biochemistry Authors: Anna Ly, Lisa Ishiguro, Denise Kim, David Im, Sung-Eun Kim, Kyoung-Jin Sohn, Ruth Croxford, Young-In Kim Source Type: research

Prenatal nutrition and the risk of adult obesity: Long-term effects of nutrition on epigenetic mechanisms regulating Gene expression
Solid epidemiological evidence indicates that part of the risk of obesity in adulthood could be programmed during prenatal development by the quality of maternal nutrition. Nevertheless, the molecular mechanisms involved are mostly unknown, which hinders our capacity to develop effective intervention policies. Here, we discuss the hypothesis that mechanisms underlying prenatal programming of adult risk are epigenetic and sensitive to environmental cues such as nutrition. While the information encoded in DNA is essentially stable, regulatory epigenetic mechanisms include reversible, covalent modifications of DNA and chromat...
Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Estanislau Navarro, Anna N. Funtikova, Montserrat F íto, Helmut Schröder Source Type: research

Prenatal Nutrition and the Risk of Adult Obesity: Long-Term Effects of Nutrition on Epigenetic Mechanisms Regulating Gene Expression
Solid epidemiological evidence indicates that part of the risk of obesity in adulthood could be programmed during prenatal development by the quality of maternal nutrition. Nevertheless, the molecular mechanisms involved are mostly unknown, which hinders our capacity to develop effective intervention policies. Here, we discuss the hypothesis that mechanisms underlying prenatal programming of adult risk are epigenetic and sensitive to environmental cues such as nutrition. While the information encoded in DNA is essentially stable, regulatory epigenetic mechanisms include reversible, covalent modifications of DNA and chromat...
Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Estanislau Navarro, Anna N. Funtikova, Montserrat Fíto, Helmut Schröder Source Type: research

The Citrus Flavonone Naringenin Reduces Lipopolysaccharide-Induced Inflammatory Pain and Leukocyte Recruitment by Inhibiting NF-κB Activation
Lipopolysaccharide (LPS) is the major structural component of Gram-negative bacteria cell wall and a highly pro-inflammatory toxin. Naringenin is found in Citrus fruits and exhibits antioxidant and anti-inflammatory properties through inhibition of NF-κB activation but its effects in LPS-induced inflammatory pain and leukocyte recruitment were not investigated yet. We investigated the effects of naringenin in mechanical hyperalgesia, thermal hyperalgesia and leukocyte recruitment induced by intraplantar injection of LPS in mice. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Felipe A. Pinho-Ribeiro, Ana C. Zarpelon, Sandra S. Mizokami, Sergio M. Borghi, Juliano Bordignon, Rangel L. Silva, Thiago M. Cunha, Jose C. Alves-Filho, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri Source Type: research

Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice
The content of the marine n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is far lower in lean than in fatty seafood. Cod fillets contain less than 2 g fat per kg, whereof approximately 50% is EPA and DHA. However, a large fraction of these n-3 PUFAs are present in the phospholipid (PL) fraction and may have high bioavailability and capacity to change the endocannabinoid profile. Here we investigated whether exchanging meat from a lean terrestrial animal with cod in a background Western diet would alter the endocannabinoid tone in mice and thereby attenuate obesity develo...
Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Ulrike Liisberg, Kristin Røen Fauske, Ondrej Kuda, Even Fjære, Lene Secher Myrmel, Nina Norberg, Livar Frøyland, Ingvild Eide Graff, Bjørn Liaset, Karsten Kristiansen, Jan Kopecky, Lise Madsen Source Type: research

Combination effects of wild rice and phytosterols on prevention of atherosclerosis in LDL receptor knockout mice
In this study, we assessed anti-atherogenic effects of a combination of wild rice and phytosterols in low-density lipoprotein receptor knockout (LDL-r-KO) mice. Male LDL-r-KO mice were divided into four groups and fed with: (1) control diet; (2) the control diet containing 60% (w/w) wild rice; (3) the control diet containing 2% (w/w) phytosterols; or (4) the control diet containing both wild rice and phytosterols for 20 weeks. (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Mohammed H. Moghadasian, Maha Alsaif, Khuong Le, Surendiran Gangadaran, Kabo Masisi, Trust Beta, Garry X. Shen Source Type: research