Higher insulin sensitivity in EDL muscle of rats fed a low-protein, high-carbohydrate diet inhibits the caspase-3 and ubiquitin-proteasome proteolytic systems but does not increase protein synthesis

Compared with the extensor longus digitorum (EDL) muscle of control rats (C), the EDL muscle of rats fed a low-protein, high-carbohydrate (LPHC) diet showed a 36% reduction in mass. Muscle mass is determined by the balance between protein synthesis and proteolysis; thus, the aim of this work was to evaluate the components involved in these processes. Compared with the muscle from C rats, the EDL muscle from LPHC diet-fed rats showed a reduction (34%) in the in vitro basal protein synthesis and a 22% reduction in the in vitro basal proteolysis suggesting that the reduction in the mass can be associated with a change in the rate of the two processes.

Source: The Journal of Nutritional Biochemistry - May 5, 2016 Category: Biochemistry Authors: Maísa Pavani dos Santos, Emanuele Batistela, Mayara Peron Pereira, Silvia Paula Gomes, Neusa Maria Zanon, Isis do Carmo Kettelhut, Christina Karatzaferi, Claudia Marlise Balbinotti Andrade, Suélem Aparecida de França, Amanda Martins Baviera, Nair Honda Source Type: research