Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice

The content of the marine n-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is far lower in lean than in fatty seafood. Cod fillets contain less than 2 g fat per kg, whereof approximately 50% is EPA and DHA. However, a large fraction of these n-3 PUFAs are present in the phospholipid (PL) fraction and may have high bioavailability and capacity to change the endocannabinoid profile. Here we investigated whether exchanging meat from a lean terrestrial animal with cod in a background Western diet would alter the endocannabinoid tone in mice and thereby attenuate obesity development and hepatic lipid accumulation.

Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Ulrike Liisberg, Kristin Røen Fauske, Ondrej Kuda, Even Fjære, Lene Secher Myrmel, Nina Norberg, Livar Frøyland, Ingvild Eide Graff, Bjørn Liaset, Karsten Kristiansen, Jan Kopecky, Lise Madsen Source Type: research