Protective Effects of Maternal Methyl Donor Supplementation on Adult Offspring of High-fat Diet-fed Dams

Obesity has become a global public health problem associated with metabolic dysfunction and chronic disorders. It has been shown that the risk of obesity and the DNA methylation profiles of the offspring can be affected by maternal nutrition, such as HFD consumption. The aim of this study was to investigate whether metabolic dysregulation and physiological abnormalities in offspring caused by maternal HFD can be alleviated by the treatment of methyl donors during pregnancy and lactation of dams.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research