The Citrus Flavonone Naringenin Reduces Lipopolysaccharide-Induced Inflammatory Pain and Leukocyte Recruitment by Inhibiting NF-κB Activation

Lipopolysaccharide (LPS) is the major structural component of Gram-negative bacteria cell wall and a highly pro-inflammatory toxin. Naringenin is found in Citrus fruits and exhibits antioxidant and anti-inflammatory properties through inhibition of NF-κB activation but its effects in LPS-induced inflammatory pain and leukocyte recruitment were not investigated yet. We investigated the effects of naringenin in mechanical hyperalgesia, thermal hyperalgesia and leukocyte recruitment induced by intraplantar injection of LPS in mice.

Source: The Journal of Nutritional Biochemistry - March 31, 2016 Category: Biochemistry Authors: Felipe A. Pinho-Ribeiro, Ana C. Zarpelon, Sandra S. Mizokami, Sergio M. Borghi, Juliano Bordignon, Rangel L. Silva, Thiago M. Cunha, Jose C. Alves-Filho, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri Source Type: research