Long non-coding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer

Long non-coding RNAs (lncRNAs) have emerged as important in cancer development and progression. The impact of diet on lncRNA expression is largely unknown. Sulforaphane (SFN), obtained from vegetables like broccoli, can prevent and suppress cancer formation. Here we tested the hypothesis that SFN attenuates the expression of cancer-associated lncRNAs. We analyzed whole genome RNA-sequencing data of normal human prostate epithelial cells and prostate cancer cells treated with 15 μM SFN or DMSO. SFN significantly altered expression of~100 lncRNAs in each cell type, and normalized the expression of some lncRNAs that were differentially expressed in cancer cells.

Source: The Journal of Nutritional Biochemistry - January 12, 2017 Category: Biochemistry Authors: Laura M. Beaver, Rachael Kuintzle, Alex Buchanan, Michelle W. Wiley, Sarah T. Glasser, Carmen P. Wong, Gavin S. Johnson, Jeff H. Chang, Christiane V. L öhr, David E. Williams, Roderick H. Dashwood, David A. Hendrix, Emily Ho Source Type: research