Quercetin induces apoptosis and autophagy in Primary Effusion Lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

In this study, we found that quercetin inhibited PI3K/AKT/mTOR and ST AT3 pathways in PEL cells and, as a consequence, it down-regulated the expression of the pro-survival cellular proteins such as c-FLIP, cyclin D1 and cMyc.

Source: The Journal of Nutritional Biochemistry - January 3, 2017 Category: Biochemistry Authors: Marisa Granato, Celeste Rizzello, Maria Saveria Gilardini Montani, Laura Cuomo, Marina Vitillo, Roberta Santarelli, Roberta Gonnella, Gabriella D'Orazi, Alberto Faggioni, Mara Cirone Source Type: research