Supra-nutritional selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS/PI3K/AKT signaling and decreased PGC-1 α expression in male Sprague–Dawley rats

Selenium (Se)-enriched milk provides anti-oxidant benefits and has therapeutic potential against cancer. However, both anti-diabetic and pro-diabetic effects have been attributed to Se. Our objective was to evaluate the effect of Se-enriched milk casein on insulin sensitivity in rats when given at the requirement of 0.25 ppm Se and supra-nutritionally on both low- and high-fat diets. 216 male Sprague –Dawley rats were fed low- or high-fat diets containing 1, 2 or 8 times the Se requirement in a randomized block design.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research