A Combination of Dietary N-3 Fatty Acids and a Cyclooxygenase-1 Inhibitor Attenuates Non-alcoholic Fatty Liver Disease in Mice

We sought to determine whether a combination of purified n-3 fatty acids (n-3) and SC-560 (SC), a COX-1 specific inhibitor, is effective in ameliorating nonalcoholic fatty liver disease in obesity. Female WT mice were fed a high fat and high cholesterol diet (HF) supplemented with n-3 in the presence or absence of SC. Mice treated with SC alone exhibited no change in liver lipids, whereas n-3-fed mice tended to have lower hepatic lipids. Mice given n-3+SC had significantly lower liver lipids compared with HF controls indicating enhanced lipid clearance.

Source: The Journal of Nutritional Biochemistry - January 25, 2017 Category: Biochemistry Authors: Viswanathan Saraswathi, Curtis Perriotte-Olson, Murali Ganesan, Cyrus V. Desouza, Yazen Alnouti, Michael J Duryee, Geoffrey M Thiele, Tara M Nordgren, Dahn L Clemens Source Type: research