Chronic maternal calcium and 25-hydroxy vitamin D deficiency in Wistar rats programs abnormal hepatic gene expression leading to hepatic steatosis in female offspring

Importance of calcium and vitamin D deficiency is well established in adult dyslipidemia. We hypothesized that maternal calcium and vitamin D deficiency could alter offspring's lipid metabolism. Our objective was to investigate the effect of maternal dietary calcium and vitamin D deficiency on lipid metabolism and liver function of the F1 generation offspring. Inter-generational calcium deficient (CaD) and vitamin D deficient (VDD) models were developed by mating normal male rats with deficient females and continuing maternal deficient diets through pregnancy and lactation.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research