Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver

The overconsumption of both saturated fats and fructose in the modern society has been related to the development of non-alcoholic fatty liver disease (NAFLD). However, the specific contribution of individual dietary components on the progression of NAFLD to non-alcoholic steatoepatitis (NASH) has been poorly investigated.Therefore, the aim of our study was to investigate the dissimilar effects of these two dietary components on selected proinflammatory and antioxidant pathways in the liver of C57BL/6 mice fed a standard (SD), a 45% saturated fat (HFAT), or a 60% fructose (HFRT) diet for 12 weeks.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research