Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle

Epidemiological studies show a dose-dependent relationship between green tea consumption and reduced risk for type 2 diabetes and cardiovascular disease. Bioactive compounds in green tea including the polyphenol epigallocatechin 3-gallate (EGCG) have insulin-mimetic actions on glucose metabolism and vascular function in isolated cell culture studies. The aim of this study is to explore acute vascular and metabolic actions of EGCG in skeletal muscle of Sprague –Dawley rats. Direct vascular and metabolic actions of EGCG were investigated using surgically isolated constant-flow perfused rat hindlimbs.

Source: The Journal of Nutritional Biochemistry - October 13, 2016 Category: Biochemistry Authors: Huei L.H. Ng, Dino Premilovac, Stephen Rattigan, Stephen M. Richards, Ranganath Muniyappa, Michael J. Quon, Michelle A. Keske Source Type: research