Dietary sphingomyelin attenuates hepatic steatosis and adipose tissue inflammation in high fat diet-induced obese mice

Western-type diets can induce obesity and related conditions such as dyslipidemia, insulin resistance, and hepatic steatosis. We evaluated the effects of milk sphingomyelin (SM) and egg SM on diet-induced obesity, the development of hepatic steatosis, and adipose inflammation in C57BL/6 J mice fed a high fat, cholesterol-enriched diet for 10 weeks. Mice were fed either a low fat diet (10% kcal from fat) (LFD, n=10), a high fat diet (60% kcal from fat) (HFD, n=14), or a high fat diet modified to contain either 0.1% (w/w) milk SM (HFMSM, n=14) or 0.1% (w/w) egg SM (HFESM, n=14).
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research