Impact of High Fat Diet on the Proteome of Mouse Liver

Chronic over-nutrition, for instance high fat diet (HFD) feeding, is a major cause of rapidly growing incidence of metabolic syndromes. However, the mechanisms underlying HFD induced adverse effects on human health are not clearly understood. HFD-fed C57BL6/J mouse has been a popular model employed to investigate the mechanisms. Yet, there is no systematic and comprehensive study of the impact of HFD on the protein profiles of the animal. Here, we present a proteome-wide study of the consequences of long-term HFD feeding.

Source: The Journal of Nutritional Biochemistry - January 25, 2016 Category: Biochemistry Authors: Outhiriaradjou Benard, Jihyeon Lim, Pasha Apontes, Xiaohong Jing, Ruth H. Angeletti, Yuling Chi Source Type: research