Physiological effects of γ-linolenic acid and sesamin on hepatic fatty acid synthesis and oxidation

Interrelated effects of γ-linolenic acid (GLA) and sesamin, a sesame lignan, on hepatic fatty acid synthesis and oxidation were examined.Rats were fed experimental diets supplemented with 0 or 2 g/kg sesamin (1:1 mixture of sesamin and episesamin), and containing 100 g/kg of either palm oil (saturated fat), safflower oil rich in linoleic acid or oil of evening primrose origin containing 43% GLA (GLA oil) for 18 d.In rats fed sesamin-free diets, GLA oil, compared with other oils, increased the activity and mRNA levels of various enzymes involved in fatty acid oxidation, except for some instances.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research