In vivo modulation of LPS induced leukotrienes generation and oxidative stress by sesame lignans

The role of inflammation and oxidative stress is critical during onset of metabolic disorders and this has been sufficiently established in literature. In the present study, we evaluated the effects of sesamol and sesamin, two important bioactive molecules present in sesame oil, on the generation of inflammatory and oxidative stress factors in LPS injected rats. Sesamol and sesamin lowered LPS induced expression of cPLA2 (61% and 56%), 5-LOX (44% and 51%), BLT-1(32% and 35%) and LTC4 synthase (49% and 50%), respectively.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research