Effect of high fructose intake on the development of hypertension in the spontaneously hypertensive rats: The role of AT1R/gp91PHOX signaling in the rostral ventrolateral medulla

Both genetic and dietary factors determine the development of hypertension. Whether dietary factor impacts the development of hereditary hypertension is unknown. Here, we evaluated the effect of daily high fructose diet (HFD) on the development of hypertension in adolescent spontaneously hypertensive rat (SHR). Six week-old SHR were randomly divided into two groups to receive HFD or normal diet (ND) for 3 weeks. The temporal profile of systolic blood pressure (SBP), alongside the sympathetic vasomotor activity, in the SHR-HFD showed significantly greater increases at 9 –12 weeks of age compared with the age-matched SHR-ND group.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research