1 α,25-Dihydroxyvitamin D Inhibits de novo Fatty Acid Synthesis and Lipid Accumulation in Metastatic Breast Cancer Cells through Downregulation of Pyruvate Carboxylase

Both increased de novo fatty acid synthesis and higher neutral lipid accumulation are a common phenotype observed in aggressive breast cancer cells, making lipid metabolism a promising target for breast cancer prevention. In the present studies we demonstrate a novel effect of the active metabolite of vitamin D, 1 α,25-dihydroxyvitamin D (1,25(OH)₂D) on lipid metabolism in malignant breast epithelial cells. Treatment of MCF10CA1a breast epithelial cells with 1,25(OH)₂D (10 nM) for five and seven days decreased the level of triacylglycerol, the most abundant form of neutral lipids, by 20%(±3.9) and 50%(± 5.9), respectively.

Source: The Journal of Nutritional Biochemistry - December 1, 2016 Category: Biochemistry Authors: Tomasz Wilmanski, Kimberly Buhman, Shawn S. Donkin, John R. Burgess, Dorothy Teegarden Source Type: research