Effects of chlorogenic acid, caffeine and coffee on components of the purinergic system of STZ-induced diabetic rats

We evaluated the effect of chlorogenic acid (CGA), caffeine (CA) and coffee (CF) on components of the purinergic system from the cerebral cortex and platelets of streptozotocin (STZ)-induced diabetic rats. Animals were divided into eight groups, control animals treated with: I – water (WT); II – CGA (5 mg/kg); III – CA (15 mg/kg); IV– CF (0.5 g/kg); and diabetic animals treated with: V – WT; VI – CGA (5 mg/kg); VII – CA (15 mg/kg); VIII – CF (0.5 g/kg). Our results showed an increase (173%) in AMP hydrolysis in the cerebral cortex of diabetic rats.

Source: The Journal of Nutritional Biochemistry - September 21, 2016 Category: Biochemistry Authors: Naiara Stefanello, Roberta Schmatz, Luciane Belmonte Pereira, Andr éia Machado Cardoso, Sabina Passamonti, Rosélia Maria Spanevello, Gustavo Thomé, Giovanna Medeiros Tavares de Oliveira, Luiza Wilges Kist, Maurício Reis Bogo, Vera Maria Morsch, Maria Source Type: research