Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps

Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine. L-arginine is necessary for cancer development and progression, including an important role in colorectal cancer pathogenesis. Furthermore, previous studies found both calcium and magnesium inhibit the transport of arginine. Thus, calcium, magnesium or calcium:magnesium intake ratio may interact with polymorphisms in the SLC7A2 gene in associations with colorectal cancer.

Source: The Journal of Nutritional Biochemistry - May 5, 2017 Category: Biochemistry Authors: Pin Sun, Xiangzhu Zhu, Martha J Shrubsole, Reid M Ness, Elizabeth A Hibler, Qiuyin Cai, Jirong Long, Zhi Chen, Guoliang Li, Lifang Hou, Walter E Smalley, Todd L. Edwards, Edward Giovannucci, Wei Zheng, Qi Dai Source Type: research