Dietary Salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat diet-induced obese rats

Previous studies suggest that dietary salecan (a water-soluble β-glucan) effectively reduce high-fat diet-induced adiposity through disturbing bile acid-promoted emulsification in mice. However, the effects of salecan on metabolic genes and metabolites involved lipid accumulation are mostly unknown. Here, we conformed that dietary 3% and 6% salecan for 4 weeks markedly decreased fat accumulation in liver and adipose tissue in high-fat diet rats, displaying a decrease in mRNA levels of SREBP1-C,FAS,SCD1,ACC1 involved in de novo lipogenesis and a reduction of levels of GPAT1,DGAT1,DGAT2 related to triglyceride (TG) synthesis.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research