The Effects of Fatty Acid Composition on Cardiac Hypertrophy and Function in Mouse Models of Diet-Induced Obesity

High fat diets (HFDs) are used frequently to study the development of cardiac dysfunction in animal models of obesity and diabetes. However, impairment in systolic function, often reported as declining ejection fraction, may not consistently occur in a given time frame which could be contributable to a variety of factors within the experimental design. One major factor may be the amounts of saturated and unsaturated fatty acids (FAs) that are present in the diet. To determine whether the FA content and composition was a critical determinant in the development of cardiac dysfunction in response to high fat feeding, we fed adult, male mice either Western diet (WD, 45% fat, 60% saturated), Surwit diet (SD, 60% fat, 90% saturated), milk-fat based diet (MFBD, 60% fat, 60% saturated), or high fat Western diet (HFWD, 60% fat, 32% saturated) for 12 weeks.

Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Son Nguyen, Dan Shao, Loreta C. Tomasi, Alyssa Braun, Ana Barbosa Marcondes de Mattos, Yong Seon Choi, Outi Villet, Nathan Roe, Carliana R. Halterman, Rong Tian, Stephen C. Kolwicz Source Type: research