Alpha-glucosidase Inhibitory Effect of Resveratrol and Piceatannol

Dietary polyphenols have been shown to inhibit α-glucosidase, an enzyme target of some anti-diabetic drugs. Resveratrol, a polyphenol found in grapes and wine, has been reported to inhibit the activity of yeast α-glucosidase. This triggered our interest to synthesize analogs and determine their effect on mammalian α-glucosidase activity. Usin g either sucrose or maltose as substrate resveratrol, piceatannol and 3′-hydroxypterostilbene showed strong inhibition of mammalian α-glucosidase activity; pinostilbene, cis- and trans-desoxyrhapontigenin had moderate inhibition.
Source: The Journal of Nutritional Biochemistry - Category: Biochemistry Authors: Source Type: research