Synergistic effect of low K and D vitamin status on arterial stiffness in a general population

Both vitamins K and D are nutrients with pleiotropic functions in human tissues. The metabolic role of these vitamins overlaps considerably in calcium homeostasis. We analyzed their potential synergetic effect on arterial stiffness. In a cross-sectional study, we analyzed aortic pulse wave velocity (aPWV) in 1023 subjects from the Czech post-MONICA study. Desphospho-uncarboxylated matrix γ-carboxyglutamate protein (dp-ucMGP), a biomarker of vitamin K status, was measured by sandwich ELISA, and 25-hydroxyvitamin D3 (25-OH-D3) by a commercial immunochemical assay.

Source: The Journal of Nutritional Biochemistry - April 22, 2017 Category: Biochemistry Authors: Otto Mayer, Jitka Seidlerov á, Peter Wohlfahrt, Jan Filipovský, Renata Cífková, Václava Černá, Alena Kučerová, Martin Pešta, Radka Fuchsová, Ondřej Topolčan, Kelly M.C. Jardon, Nadja E.A. Drummen, Cees Vermeer Source Type: research