The phytochemical 3,3 ′-Diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells

Androgen receptor (AR) is a nuclear receptor transcription factor that plays a central role in normal prostate physiology as well as in prostate cancer biology (PCa). Phytochemicals like 3,3 ′-Diindolylmethane (DIM) have emerged as promising therapeutic agents against PCa. DIM has been shown to influence both AR activity and other epigenetic regulators in PCa cells. However, it is not known if DIM contributes to PCa suppression via epigenetic regulation of AR target genes. Here we ass essed epigenetic regulation of important AR-target genes in LNCaP PCa cells treated with DIM.

Source: The Journal of Nutritional Biochemistry - May 25, 2017 Category: Biochemistry Authors: Zoraya Palomera-Sanchez, Gregory W. Watson, Carmen P. Wong, Laura M. Beaver, David E. Williams, Roderick H. Dashwood, Emily Ho Source Type: research